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Tbio
SYNE2
Nesprin-2

Protein Summary
Description
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341472
  • ENSP00000344528
  • ENSG00000054654
  • ENST00000344113
  • ENSP00000341781
  • ENST00000358025
  • ENSP00000350719
  • ENST00000458046
  • ENSP00000391937
  • ENST00000639659
  • ENSP00000492333

Symbol
  • KIAA1011
  • NUA
  • NUA
  • EDMD5
  • KASH2
  • Nesp2
  • TROPH
  • NUANCE
  • SYNE-2
  • Nesprin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
virus perturbation
0.95
cellular component
0.87
protein domain
0.85
transcription factor
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.92   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0