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Tbio
SYNCRIP
Heterogeneous nuclear ribonucleoprotein Q

Protein Summary
Description
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with sy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355238
  • ENSP00000347380
  • ENSG00000135316
  • ENST00000369622
  • ENSP00000358635

Symbol
  • HNRPQ
  • NSAP1
  • PP68
  • NSAP1
  • GRYRBP
  • HNRNPQ
  • HNRPQ1
  • GRY-RBP
  • hnRNP-Q
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
transcription factor perturbation
1
disease perturbation
0.97
transcription factor binding site profile
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.62   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.62   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (344)
RBMXL1
Tdark
Novelty:  0.81422952
p_int:  0.999748675
p_ni:  0.000251325
Score:  0.718
Data Source:  BioPlex,STRINGDB
ANGEL2
Tbio
Novelty:  0.26130802
p_int:  0.998401783
p_ni:  0.001597526
p_wrong:  6.91e-7
Score:  0.192
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.994941764
p_ni:  0.005058236
Score:  0.814
Data Source:  BioPlex,STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.993237545
p_ni:  0.006762455
Score:  0.27
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.990407089
p_ni:  0.009592911
Score:  0.235
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.987269293
p_ni:  0.012730707
Score:  0.696
Data Source:  BioPlex,STRINGDB
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.961581915
p_ni:  0.038418085
Score:  0.56
Data Source:  BioPlex,STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.926191736
p_ni:  0.073808264
Score:  0.209
Data Source:  BioPlex,STRINGDB
HDLBP
Tbio
Novelty:  0.00979636
p_int:  0.899727534
p_ni:  0.100272466
Score:  0.326
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.891693777
p_ni:  0.108306223
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
13
neutrophil count
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
13
neutrophil count
1
11.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin binding cytoplasmic RNA interacting protein
VGNC:9960
462866
Macaque
synaptotagmin binding cytoplasmic RNA interacting protein
696756
Mouse
MGI:1891690
56403
Rat
RGD:1305683
363113
Dog
synaptotagmin binding cytoplasmic RNA interacting protein
VGNC:47024
474986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin binding cytoplasmic RNA interacting protein
Macaque
synaptotagmin binding cytoplasmic RNA interacting protein
Mouse
Rat
Dog
synaptotagmin binding cytoplasmic RNA interacting protein
Publication Statistics
PubMed Score 73.62
PubMed score by year
PubTator Score 31.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title