Protein Summary
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
- ENST00000373484
- ENSP00000362583
- ENSG00000162520
- ENST00000409190
- ENSP00000386439
- SYNC1
- SYNC1
- SYNCOILIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
histone modification site profile | 0.82 | ||
tissue sample | 0.73 | ||
microRNA | 0.64 | ||
PubMedID | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.44 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.44 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
DES
Novelty: 0.00651741
p_int: 0.999999942
p_ni: 9e-9
p_wrong: 4.8e-8
Score: 0.718
Data Source: BioPlex,STRINGDB
TJAP1
Novelty: 0.008967
p_int: 0.999999865
p_ni: 1.35e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
MAP3K7
Family: Kinase
Novelty: 0.00540177
p_int: 0.999998469
p_ni: 0.00000153
Data Source: BioPlex
INA
Novelty: 0.00708581
p_int: 0.999993008
p_ni: 0.000006992
Score: 0.311
Data Source: BioPlex,STRINGDB
SYNM
Novelty: 0.01167838
p_int: 0.999991051
p_ni: 0.000008947
p_wrong: 2e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
NEFM
Novelty: 0.00239134
p_int: 0.999985282
p_ni: 0.000014718
Score: 0.667
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (6)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 60.2 | |||||
body mass index | 1 | 1 | 1 | 59 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 33.1 | |||||
1 | 1 | 1 | 2 | ||||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 60.2 | |||||
body mass index | 1 | 59 | |||||
visceral adipose tissue measurement | 1 | 33.1 | |||||
1 | 2 | ||||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | syncoilin, intermediate filament protein | VGNC:10957 | 456720 | |||||
Mouse | MGI:1916078 | 68828 | ||||||
Rat | RGD:1307970 | 362606 | ||||||
Dog | syncoilin, intermediate filament protein | VGNC:49861 | 487303 | |||||
Horse | syncoilin, intermediate filament protein | VGNC:50770 | 100070162 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | syncoilin, intermediate filament protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | syncoilin, intermediate filament protein | |||||
Horse | syncoilin, intermediate filament protein | |||||
Publication Statistics
PubMed Score 25.44
PubMed score by year
PubTator Score 12.03
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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