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Tbio
SYN2
Synapsin-2

Protein Summary
Description
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620175
  • ENSP00000484916
  • ENSG00000157152
  • ENST00000621198
  • ENSP00000480050

Symbol
  • SYNII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.88
microRNA
0.87
molecular function
0.76
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.51   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.51   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999974836
p_ni:  0.000025151
p_wrong:  1.3e-8
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999040178
p_ni:  0.000169009
p_wrong:  0.000790813
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.995472844
p_ni:  0.000022573
p_wrong:  0.004504583
Data Source:  BioPlex
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
p_int:  0.994685241
p_ni:  0.000005903
p_wrong:  0.005308856
Score:  0.187
Data Source:  BioPlex,STRINGDB
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.960437439
p_ni:  0.002350489
p_wrong:  0.037212072
Score:  0.165
Data Source:  BioPlex,STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.981
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.979
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.971
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.968
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Dopamine Neurotransmitter Release Cycle (R-HSA-212676)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Serotonin Neurotransmitter Release Cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Dopamine Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Serotonin Neurotransmitter Release Cycle
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
4
2
96.5
waist-hip ratio
2
17
17
93.2
BMI-adjusted waist-hip ratio
1
15
15
93.1
low density lipoprotein cholesterol measurement
5
3
5
92.9
lymphocyte count
3
2
3
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
2
96.5
waist-hip ratio
17
93.2
BMI-adjusted waist-hip ratio
15
93.1
low density lipoprotein cholesterol measurement
5
92.9
lymphocyte count
3
86.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:103020
20965
Rat
RGD:3798
29179
Dog
synapsin II
VGNC:54371
484652
Horse
synapsin II
VGNC:23797
100057285
Cow
synapsin II
VGNC:35515
782758
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
synapsin II
Horse
synapsin II
Cow
synapsin II
Publication Statistics
PubMed Score 180.51
PubMed score by year
PubTator Score 94.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title