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Tclin
SYK
Tyrosine-protein kinase SYK

Protein Summary
Description
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375746
  • ENSP00000364898
  • ENSG00000165025
  • ENST00000375747
  • ENSP00000364899
  • ENST00000375751
  • ENSP00000364904
  • ENST00000375754
  • ENSP00000364907

Symbol
  • p72-Syk
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1855.19   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 1438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1855.19   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 1438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1429
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (446)
VAV1
Tchem
Novelty:  0.00180518
Score:  0.999
Data Source:  Reactome,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.998
Data Source:  Reactome,STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.997
Data Source:  Reactome,STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.994
Data Source:  Reactome,STRINGDB
CBL
Tbio
Family:  Enzyme
Novelty:  0.00114929
Score:  0.993
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.991
Data Source:  Reactome,STRINGDB
LAT
Tbio
Novelty:  0.00738419
Score:  0.99
Data Source:  Reactome,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.988
Data Source:  Reactome,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.988
Data Source:  Reactome,STRINGDB
CLEC7A
Tbio
Novelty:  0.00162014
Score:  0.988
Data Source:  Reactome,STRINGDB
Pathways (80)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (78)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
70.1
monocyte count
1
1
1
61.4
mean platelet volume
2
2
2
56
mean corpuscular volume
1
1
1
55.2
1
1
0
2.2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
70.1
monocyte count
1
61.4
mean platelet volume
2
56
mean corpuscular volume
1
55.2
0
2.2
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spleen associated tyrosine kinase
VGNC:13975
464586
Macaque
spleen associated tyrosine kinase
704102
Mouse
MGI:99515
20963
Rat
RGD:3796
25155
Dog
spleen associated tyrosine kinase
VGNC:47021
484196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spleen associated tyrosine kinase
Macaque
spleen associated tyrosine kinase
Mouse
Rat
Dog
spleen associated tyrosine kinase
Publication Statistics
PubMed Score 1855.19
PubMed score by year
PubTator Score 1083.85
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title