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Tbio
SYF2
Pre-mRNA-splicing factor SYF2

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236273
  • ENSP00000236273
  • ENSG00000117614
  • ENST00000354361
  • ENSP00000346330

Symbol
  • CBPIN
  • GCIPIP
  • P29
  • CBPIN
  • NTC31
  • fSAP29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor binding site profile
0.87
histone modification site profile
0.84
tissue sample
0.71
cell type or tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.33   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (245)
GPATCH1
Tdark
Novelty:  0.93318176
p_int:  0.999993109
p_ni:  0.000006891
Score:  0.816
Data Source:  BioPlex,STRINGDB
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999988658
p_ni:  0.000011342
Score:  0.978
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999978223
p_ni:  0.000021777
Score:  0.656
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999955161
p_ni:  0.000044839
Score:  0.782
Data Source:  BioPlex,STRINGDB
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.999951036
p_ni:  0.000048964
Score:  0.833
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999941377
p_ni:  0.00005862
p_wrong:  3e-9
Score:  0.809
Data Source:  BioPlex,STRINGDB
DHX35
Tdark
Family:  Enzyme
Novelty:  0.26052594
p_int:  0.999935841
p_ni:  0.000064159
Score:  0.803
Data Source:  BioPlex,STRINGDB
CDC40
Tbio
Novelty:  0.03139044
p_int:  0.999908178
p_ni:  0.000091821
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.999881432
p_ni:  0.000118568
Score:  0.997
Data Source:  BioPlex,STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
p_int:  0.999849304
p_ni:  0.000150696
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
3
3
90.6
platelet crit
2
2
2
89.7
platelet count
1
2
2
89.1
1
3
3
88.7
mean reticulocyte volume
1
1
1
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
90.6
platelet crit
2
89.7
platelet count
2
89.1
3
88.7
mean reticulocyte volume
1
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SYF2 pre-mRNA splicing factor
VGNC:8512
456634
Macaque
SYF2 pre-mRNA splicing factor
719564
Mouse
MGI:1915842
68592
Rat
RGD:621592
170933
Dog
SYF2 pre-mRNA splicing factor
478184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SYF2 pre-mRNA splicing factor
Macaque
SYF2 pre-mRNA splicing factor
Mouse
Rat
Dog
SYF2 pre-mRNA splicing factor
Publication Statistics
PubMed Score 18.33
PubMed score by year
PubTator Score 99.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title