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Tbio
SYDE1
Rho GTPase-activating protein SYDE1

Protein Summary
Description
GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469). The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342784
  • ENSP00000341489
  • ENSG00000105137
  • ENST00000600440
  • ENSP00000470733

Symbol
  • 7h3
  • SYD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
protein complex
0.61
cell type or tissue
0.59
tissue sample
0.57
small molecule perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.66   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.66   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.999994756
p_ni:  1.25e-7
p_wrong:  0.000005119
Score:  0.182
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.995407075
p_ni:  0.004592925
Score:  0.821
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.994480156
p_ni:  0.005519843
p_wrong:  1e-9
Data Source:  BioPlex
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.967885662
p_ni:  0.032114337
Score:  0.183
Data Source:  BioPlex,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
p_int:  0.938378297
p_ni:  0.061621703
Score:  0.622
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.932979465
p_ni:  0.067020412
p_wrong:  1.23e-7
Score:  0.638
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.927479118
p_ni:  0.072520882
Score:  0.527
Data Source:  BioPlex,STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
p_int:  0.889013101
p_ni:  0.109135171
p_wrong:  0.001851728
Score:  0.189
Data Source:  BioPlex,STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.916
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-Toxoplasma gondii IgG measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Anti-Toxoplasma gondii IgG measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synapse defective Rho GTPase homolog 1
VGNC:10271
747974
Mouse
MGI:1918959
71709
Rat
RGD:1305857
362842
Dog
synapse defective Rho GTPase homolog 1
VGNC:47020
100856120
Cow
synapse defective Rho GTPase homolog 1
VGNC:35510
789472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synapse defective Rho GTPase homolog 1
Mouse
Rat
Dog
synapse defective Rho GTPase homolog 1
Cow
synapse defective Rho GTPase homolog 1
Publication Statistics
PubMed Score 18.66
PubMed score by year
PubTator Score 6.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title