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Tdark
SYCE3
Synaptonemal complex central element protein 3

Protein Summary
Description
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402753
  • ENSP00000385122
  • ENSG00000217442
  • ENST00000406915
  • ENSP00000385480

Symbol
  • C22orf41
  • THEG2
  • THEG2
  • C22orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.5
kinase perturbation
0.48
tissue
0.47
cellular component
0.46
phenotype
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
CENPE
Tchem
Novelty:  0.00458125
p_int:  0.999999999
p_ni:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
MAP3K15
Tchem
Family:  Kinase
Novelty:  0.12112018
p_int:  0.999999947
p_ni:  5.2e-8
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.516
Data Source:  BioPlex,STRINGDB
NIN
Tbio
Novelty:  0.01312714
p_int:  0.999999851
p_ni:  4.5e-8
p_wrong:  1.05e-7
Data Source:  BioPlex
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999999734
p_ni:  2.65e-7
p_wrong:  1e-9
Data Source:  BioPlex
RUNX1T1
Tbio
Novelty:  0.0039633
p_int:  0.99999949
p_ni:  5.09e-7
p_wrong:  1e-9
Data Source:  BioPlex
PRDM6
Tbio
Family:  TF; Epigenetic
Novelty:  0.04172889
p_int:  0.999999255
p_ni:  6.35e-7
p_wrong:  1.1e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
KIFC3
Tbio
Novelty:  0.0662353
p_int:  0.999995912
p_ni:  3.97e-7
p_wrong:  0.000003691
Score:  0.224
Data Source:  BioPlex,STRINGDB
KIZ
Tbio
Novelty:  0.0644373
p_int:  0.999993852
p_ni:  0.000003403
p_wrong:  0.000002744
Score:  0.516
Data Source:  BioPlex,STRINGDB
PEX11B
Tbio
Novelty:  0.04285427
p_int:  0.999979945
p_ni:  0.000003643
p_wrong:  0.000016412
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
97.9
mean corpuscular hemoglobin
3
3
3
95.8
red blood cell distribution width
4
4
4
93.5
mean reticulocyte volume
1
4
4
89.3
blood metabolite measurement
2
3
4
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
97.9
mean corpuscular hemoglobin
3
95.8
red blood cell distribution width
4
93.5
mean reticulocyte volume
4
89.3
blood metabolite measurement
4
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 3
VGNC:6001
747308
Mouse
MGI:1922709
75459
Rat
RGD:1586367
689933
Dog
synaptonemal complex central element protein 3
VGNC:47016
100685583
Horse
synaptonemal complex central element protein 3
VGNC:23792
106782732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptonemal complex central element protein 3
Mouse
Rat
Dog
synaptonemal complex central element protein 3
Horse
synaptonemal complex central element protein 3
Publication Statistics
PubMed Score 7.97
PubMed score by year
PubTator Score 0.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title