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Tbio
SYBU
Syntabulin

Protein Summary
Description
Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276646
  • ENSP00000276646
  • ENSG00000147642
  • ENST00000399066
  • ENSP00000382019
  • ENST00000408889
  • ENSP00000386196
  • ENST00000408908
  • ENSP00000386154
  • ENST00000422135
  • ENSP00000407118
  • ENST00000433638
  • ENSP00000403544
  • ENST00000440310
  • ENSP00000404369
  • ENST00000446070
  • ENSP00000414748
  • ENST00000528331
  • ENSP00000436041
  • ENST00000528647
  • ENSP00000432501
  • ENST00000532779
  • ENSP00000436266
  • ENST00000533065
  • ENSP00000432962
  • ENST00000533171
  • ENSP00000434679
  • ENST00000533895
  • ENSP00000433446

Symbol
  • GOLSYN
  • KIAA1472
  • OCSYN
  • SNPHL
  • GOLSYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
small molecule perturbation
0.76
tissue sample
0.68
virus perturbation
0.64
histone modification site profile
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
BICD1
Tbio
Novelty:  0.02109123
p_int:  0.999998293
p_ni:  0.000001707
Score:  0.247
Data Source:  BioPlex,STRINGDB
CEP162
Tdark
Novelty:  0.03171049
p_int:  0.99999653
p_ni:  0.00000347
Score:  0.193
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999972242
p_ni:  0.000027758
Score:  0.242
Data Source:  BioPlex,STRINGDB
SNPH
Tbio
Novelty:  0.02572001
p_int:  0.999925599
p_wrong:  0.000074401
Score:  0.47
Data Source:  BioPlex,STRINGDB
CLASP1
Tbio
Novelty:  0.02763985
p_int:  0.999902361
p_ni:  0.000092763
p_wrong:  0.000004876
Score:  0.601
Data Source:  BioPlex,STRINGDB
MARC2
Tbio
Novelty:  0.05210077
p_int:  0.999895111
p_ni:  0.000081337
p_wrong:  0.000023553
Score:  0.216
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999579904
p_ni:  4.18e-7
p_wrong:  0.000419678
Data Source:  BioPlex
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.998925546
p_ni:  0.001063127
p_wrong:  0.000011327
Score:  0.583
Data Source:  BioPlex,STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.953587006
p_ni:  0.046412993
p_wrong:  1e-9
Data Source:  BioPlex
SNAPIN
Tbio
Novelty:  0.02019383
p_int:  0.883981863
p_ni:  0.116018137
Score:  0.528
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ankle brachial index
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ankle brachial index
1
1.4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntabulin
VGNC:778
472844
Macaque
syntabulin
699436
Mouse
MGI:2442392
319613
Rat
RGD:1564335
500865
Dog
syntabulin
VGNC:47013
475076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntabulin
Macaque
syntabulin
Mouse
Rat
Dog
syntabulin
Publication Statistics
PubMed Score 16.52
PubMed score by year
PubTator Score 8.13
PubTator score by year
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Related Publications
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PMID
Year
Title