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Tbio
SUSD6
Sushi domain-containing protein 6

Protein Summary
Description
May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627). Plays a role in preventing tumor onset (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342745
  • ENSP00000344424
  • ENSG00000100647

Symbol
  • DRAGO
  • KIAA0247
  • DRAGO
  • KIAA0247
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.96
transcription factor binding site profile
0.85
virus perturbation
0.85
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999988863
p_ni:  0.000011137
Score:  0.261
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999495716
p_ni:  0.000504284
Score:  0.235
Data Source:  BioPlex,STRINGDB
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.82474747
p_ni:  0.17525253
Score:  0.239
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
Score:  0.716
Data Source:  STRINGDB
KLHL14
Tbio
Novelty:  0.1214402
Score:  0.704
Data Source:  STRINGDB
PRELID3A
Tbio
Novelty:  1.54594896
Score:  0.658
Data Source:  STRINGDB
FAM168A
Tbio
Novelty:  0.08308907
Score:  0.627
Data Source:  STRINGDB
BRMS1
Tbio
Novelty:  0.01689792
Score:  0.626
Data Source:  STRINGDB
DHRS7
Tbio
Family:  Enzyme
Novelty:  0.16713756
Score:  0.578
Data Source:  STRINGDB
PLEKHD1
Tdark
Novelty:  3.32007841
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
71
balding measurement
1
1
1
64.9
mean corpuscular volume
1
2
2
44
appendicular lean mass
1
1
1
14.2
platelet crit
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
71
balding measurement
1
64.9
mean corpuscular volume
2
44
appendicular lean mass
1
14.2
platelet crit
1
5.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sushi domain containing 6
VGNC:3308
467490
Mouse
MGI:2444661
217684
Dog
sushi domain containing 6
VGNC:47000
490752
Horse
sushi domain containing 6
VGNC:49362
100053211
Cow
sushi domain containing 6
VGNC:35490
510837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sushi domain containing 6
Mouse
Dog
sushi domain containing 6
Horse
sushi domain containing 6
Cow
sushi domain containing 6
Publication Statistics
PubMed Score 12.68
PubMed score by year
PubTator Score 1.96
PubTator score by year
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Related Publications
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PMID
Year
Title