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Tdark
SUSD3
Sushi domain-containing protein 3

Protein Summary
Description
May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375469
  • ENSP00000364618
  • ENSG00000157303
  • ENST00000375472
  • ENSP00000364621
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
phenotype
0.69
PubMedID
0.67
tissue sample
0.61
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
S100A7A
Tbio
Novelty:  0.06518939
p_int:  0.999973951
p_ni:  0.000026049
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
CD207
Tbio
Novelty:  0.00313729
p_int:  0.999877063
p_ni:  0.000011973
p_wrong:  0.000110964
Score:  0.211
Data Source:  BioPlex,STRINGDB
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.997516982
p_ni:  0.00164276
p_wrong:  0.000840259
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.995554968
p_ni:  0.004445032
Data Source:  BioPlex
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
p_int:  0.994229778
p_ni:  0.005761562
p_wrong:  0.00000866
Score:  0.18
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.99250552
p_ni:  0.003230268
p_wrong:  0.004264212
Data Source:  BioPlex
EVPL
Tbio
Novelty:  0.00274279
p_int:  0.991560864
p_ni:  0.008407133
p_wrong:  0.000032003
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.989070429
p_ni:  0.01092957
Score:  0.204
Data Source:  BioPlex,STRINGDB
PPL
Tbio
Novelty:  0.00684645
p_int:  0.981049798
p_ni:  0.018950194
p_wrong:  8e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
TRIM29
Tbio
Novelty:  0.02572789
p_int:  0.979558555
p_ni:  0.020441445
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
1
9.8
79.9
serum alanine aminotransferase measurement
2
1
1
8.6
72.4
blood protein measurement
10
3
10
67.3
mean platelet volume
2
2
2
59.5
L lactate dehydrogenase measurement
1
1
1
52.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
9.8
79.9
serum alanine aminotransferase measurement
1
8.6
72.4
blood protein measurement
10
67.3
mean platelet volume
2
59.5
L lactate dehydrogenase measurement
1
52.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sushi domain containing 3
VGNC:4872
744727
Macaque
sushi domain containing 3
717086
Mouse
MGI:1913579
66329
Rat
RGD:1310933
306810
Dog
sushi domain containing 3
VGNC:46999
106559543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sushi domain containing 3
Macaque
sushi domain containing 3
Mouse
Rat
Dog
sushi domain containing 3
Publication Statistics
PubMed Score 3.50
PubMed score by year
PubTator Score 2.48
PubTator score by year
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Related Publications
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PMID
Year
Title