You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SURF2
Surfeit locus protein 2

Protein Summary
Description
This gene shares a bidirectional promoter with surfeit 1 (SURF1; GeneID: 6834), which is located on the opposite strand. It encodes a conserved protein that is expressed in a variety of tissues. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371964
  • ENSP00000361032
  • ENSG00000148291

Symbol
  • SURF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.71
histone modification site profile
0.7
tissue sample
0.64
cellular component
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
C5orf22
Tdark
Novelty:  1.29325352
p_int:  0.999997032
p_ni:  0.000001284
p_wrong:  0.000001684
Score:  0.207
Data Source:  BioPlex,STRINGDB
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.999988858
p_ni:  0.000001514
p_wrong:  0.000009628
Score:  0.499
Data Source:  BioPlex,STRINGDB
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.999932307
p_ni:  0.000067644
p_wrong:  4.9e-8
Data Source:  BioPlex
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.999850559
p_ni:  0.000148883
p_wrong:  5.59e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999710622
p_ni:  0.000259461
p_wrong:  0.000029917
Score:  0.18
Data Source:  BioPlex,STRINGDB
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  0.998673734
p_ni:  0.001325901
p_wrong:  3.65e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
RIOX2
Tbio
Family:  Epigenetic
Novelty:  0.03254245
p_int:  0.99813354
p_ni:  0.00186646
Score:  0.499
Data Source:  BioPlex,STRINGDB
RPL5
Tbio
Novelty:  0.00663792
p_int:  0.997804197
p_ni:  0.002195803
Data Source:  BioPlex
SSB
Tbio
Novelty:  0.00230478
p_int:  0.988254579
p_ni:  0.011745421
Score:  0.265
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.977489058
p_ni:  0.021769599
p_wrong:  0.000741344
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (159)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
13
13
36
2.9
99.8
alkaline phosphatase measurement
6
9
9
8.8
99.8
9
11
2
1.5
99.7
total cholesterol measurement
11
14
35
3
99.7
hemoglobin measurement
7
5
10
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
36
2.9
99.8
alkaline phosphatase measurement
9
8.8
99.8
2
1.5
99.7
total cholesterol measurement
35
3
99.7
hemoglobin measurement
10
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
surfeit 2
VGNC:14395
100608859
Macaque
surfeit 2
100430364
Mouse
MGI:98444
20931
Dog
surfeit 2
VGNC:46995
491268
Horse
surfeit 2
VGNC:23769
100146305
Species
Name
OMA
EggNOG
Inparanoid
Chimp
surfeit 2
Macaque
surfeit 2
Mouse
Dog
surfeit 2
Horse
surfeit 2
Publication Statistics
PubMed Score 8.04
PubMed score by year
PubTator Score 3.31
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title