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Tbio
SUPT7L
STAGA complex 65 subunit gamma

Protein Summary
Description
SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337768
  • ENSP00000336750
  • ENSG00000119760
  • ENST00000404798
  • ENSP00000385218
  • ENST00000405491
  • ENSP00000384469
  • ENST00000406540
  • ENSP00000385436
  • ENST00000464789
  • ENSP00000441110

Symbol
  • KIAA0764
  • SPT7L
  • STAF65
  • SUPT7H
  • STAF65G
  • STAF65(gamma)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
virus perturbation
0.92
transcription factor binding site profile
0.71
microRNA
0.65
biological process
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999966
p_ni:  3.3e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999999054
p_ni:  9.17e-7
p_wrong:  2.9e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999999043
p_ni:  9.56e-7
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999996689
p_ni:  0.000003286
p_wrong:  2.5e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999991924
p_ni:  0.000008009
p_wrong:  6.7e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.99997046
p_ni:  0.000029537
p_wrong:  3e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.999913381
p_ni:  0.000086583
p_wrong:  3.6e-8
Data Source:  BioPlex
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999903166
p_ni:  0.000051092
p_wrong:  0.000045743
Score:  0.994
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999869264
p_ni:  0.000123585
p_wrong:  0.000007151
Score:  0.991
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.996473225
p_ni:  0.000981439
p_wrong:  0.002545336
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
8
9
6.6
99.1
appendicular lean mass
3
3
3
80
C-reactive protein measurement
1
3
3
79.9
metabolic syndrome
1
3
3
75.4
sleep duration
2
1
2
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
6.6
99.1
appendicular lean mass
3
80
C-reactive protein measurement
3
79.9
metabolic syndrome
3
75.4
sleep duration
2
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT7 like, STAGA complex gamma subunit
VGNC:49085
459110
Macaque
SPT7 like, STAGA complex gamma subunit
702030
Mouse
MGI:1919445
72195
Rat
RGD:1562206
313905
Dog
STAGA complex 65 subunit gamma
475708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT7 like, STAGA complex gamma subunit
Macaque
SPT7 like, STAGA complex gamma subunit
Mouse
Rat
Dog
STAGA complex 65 subunit gamma
Publication Statistics
PubMed Score 10.73
PubMed score by year
PubTator Score 1.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title