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Tbio
SUPT3H
Transcription initiation protein SPT3 homolog

Protein Summary
Description
Probable transcriptional activator.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371459
  • ENSP00000360514
  • ENSG00000196284
  • ENST00000371460
  • ENSP00000360515
  • ENST00000475057
  • ENSP00000436411

Symbol
  • SPT3
  • SPT3
  • SPT3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
trait
0.93
transcription factor binding site profile
0.93
histone modification site profile
0.91
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.04   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.04   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999896
p_ni:  1.04e-7
Score:  0.99
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.99999557
p_ni:  0.000003915
p_wrong:  5.15e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999988463
p_ni:  0.000011516
p_wrong:  2.1e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999987608
p_ni:  0.000009853
p_wrong:  0.000002539
Score:  0.991
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999910966
p_ni:  0.000025683
p_wrong:  0.000063351
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.9983262
p_ni:  0.000006094
p_wrong:  0.001667706
Score:  0.997
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.992959079
p_ni:  0.000005442
p_wrong:  0.007035479
Score:  0.997
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.768940861
p_ni:  0.000376401
p_wrong:  0.230682738
Data Source:  BioPlex
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.999
Data Source:  STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
10
17
99.3
body height
3
3
3
88.7
appendicular lean mass
1
5
5
76.5
bone density
2
5
6
74
3
4
0
1.1
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
17
99.3
body height
3
88.7
appendicular lean mass
5
76.5
bone density
6
74
0
1.1
72.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT3 homolog, SAGA and STAGA complex component
VGNC:7932
462737
Macaque
SPT3 homolog, SAGA and STAGA complex component
703447
Mouse
MGI:1923723
109115
Rat
RGD:1591316
685697
Dog
SPT3 homolog, SAGA and STAGA complex component
VGNC:46990
474922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT3 homolog, SAGA and STAGA complex component
Macaque
SPT3 homolog, SAGA and STAGA complex component
Mouse
Rat
Dog
SPT3 homolog, SAGA and STAGA complex component
Publication Statistics
PubMed Score 7.04
PubMed score by year
PubTator Score 18.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title