Tbio SUPT20H Transcription factor SPT20 homolog

Protein Summary

Description

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.

Uniprot Accession IDs

• Q8NEM7
• E7ER46
• Q71RF3
• Q9Y6A6

Gene Name

• SUPT20H

Ensembl ID

• ENST00000350612
• ENSP00000218894
• ENSG00000102710
• ENST00000356185
• ENSP00000348512
• ENST00000360252
• ENSP00000353388
• ENST00000464744
• ENSP00000419754
• ENST00000475892
• ENSP00000417510

Symbol

• C13orf19
• FAM48A
• C13
• FP757
• P38IP
• SPT20
• FAM48A
• C13orf19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.8
histone modification site profile	0.67
hub protein	0.67
tissue	0.62
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Spt20 Homolog

DTO Classes

Protein / Transcription Factor / Transcription Factor Spt20 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

TAF5L

Tbio

Family:  Enzyme

Novelty:  0.29525944

p_int:  0.999999393

p_ni:  6.07e-7

Score:  0.967

Data Source:  BioPlex,STRINGDB

KAT2B

Tchem

Family:  Epigenetic

Novelty:  0.00172126

p_int:  0.999999374

p_ni:  6.26e-7

Score:  0.981

Data Source:  BioPlex,STRINGDB

SUPT7L

Tdark

Novelty:  0.20661559

p_int:  0.999999054

p_ni:  9.17e-7

p_wrong:  2.9e-8

Score:  0.983

Data Source:  BioPlex,STRINGDB

TADA2B

Tbio

Family:  TF

Novelty:  0.06387677

p_int:  0.999998966

p_ni:  9.55e-7

p_wrong:  8e-8

Score:  0.998

Data Source:  BioPlex,STRINGDB

TADA3

Tbio

Novelty:  0.01743814

p_int:  0.999990028

p_ni:  0.000009972

Score:  0.999

Data Source:  BioPlex,STRINGDB

KAT2A

Tchem

Family:  Epigenetic

Novelty:  0.00238831

p_int:  0.999989102

p_ni:  0.000010898

Score:  0.994

Data Source:  BioPlex,STRINGDB

SUPT3H

Tbio

Novelty:  0.13202683

p_int:  0.999987608

p_ni:  0.000009853

p_wrong:  0.000002539

Score:  0.991

Data Source:  BioPlex,STRINGDB

TAF12

Tbio

Novelty:  0.04352637

p_int:  0.999982428

p_ni:  0.000009702

p_wrong:  0.00000787

Score:  0.995

Data Source:  BioPlex,STRINGDB

TRRAP

Tbio

Novelty:  0.01517245

p_int:  0.999980271

p_ni:  0.000019729

Score:  0.995

Data Source:  BioPlex,STRINGDB

TADA1

Tdark

Novelty:  0.09903801

p_int:  0.999966878

p_ni:  0.000033118

p_wrong:  4e-9

Score:  0.998

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Chromatin modifying enzymes (R-HSA-3247509)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
HATs acetylate histones	107 targets	R-HSA-3214847

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (3)

Processes (4)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
transcription coregulator activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	1	1		65.5
bone density	EFO_0003923	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1		65.5
bone density	EFO_0003923	1		24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Autophagy
Complete proteome
Developmental protein
Gastrulation
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
bone density
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
pigmentation phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SPT20 homolog, SAGA complex component	VGNC:7305	452704
Macaque	SPT20 homolog, SAGA complex component		696174
Mouse	suppressor of Ty 20	MGI:1929651	56790
Rat	SPT20 homolog, SAGA complex component	RGD:1307812	361946
Dog	SPT20 homolog, SAGA complex component		477299

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SPT20 homolog, SAGA complex component
Macaque	SPT20 homolog, SAGA complex component
Mouse	suppressor of Ty 20
Rat	SPT20 homolog, SAGA complex component
Dog	SPT20 homolog, SAGA complex component

Publication Statistics

PubMed Score 149.27

PubMed score by year

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PubTator Score 22.50

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (8)

Items per page:

10

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PMID	Year	Title