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Tbio
SUPT20H
Transcription factor SPT20 homolog

Protein Summary
Description
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350612
  • ENSP00000218894
  • ENSG00000102710
  • ENST00000356185
  • ENSP00000348512
  • ENST00000360252
  • ENSP00000353388
  • ENST00000464744
  • ENSP00000419754
  • ENST00000475892
  • ENSP00000417510

Symbol
  • C13orf19
  • FAM48A
  • C13
  • FP757
  • P38IP
  • SPT20
  • FAM48A
  • C13orf19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.8
histone modification site profile
0.67
hub protein
0.67
tissue
0.62
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.999999393
p_ni:  6.07e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
p_int:  0.999999374
p_ni:  6.26e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
SUPT7L
Tdark
Novelty:  0.20661559
p_int:  0.999999054
p_ni:  9.17e-7
p_wrong:  2.9e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999998966
p_ni:  9.55e-7
p_wrong:  8e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999990028
p_ni:  0.000009972
Score:  0.999
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
p_int:  0.999989102
p_ni:  0.000010898
Score:  0.994
Data Source:  BioPlex,STRINGDB
SUPT3H
Tbio
Novelty:  0.13202683
p_int:  0.999987608
p_ni:  0.000009853
p_wrong:  0.000002539
Score:  0.991
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999982428
p_ni:  0.000009702
p_wrong:  0.00000787
Score:  0.995
Data Source:  BioPlex,STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
p_int:  0.999980271
p_ni:  0.000019729
Score:  0.995
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999966878
p_ni:  0.000033118
p_wrong:  4e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
65.5
bone density
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
65.5
bone density
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT20 homolog, SAGA complex component
VGNC:7305
452704
Macaque
SPT20 homolog, SAGA complex component
696174
Mouse
MGI:1929651
56790
Rat
RGD:1307812
361946
Dog
SPT20 homolog, SAGA complex component
477299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT20 homolog, SAGA complex component
Macaque
SPT20 homolog, SAGA complex component
Mouse
Rat
Dog
SPT20 homolog, SAGA complex component
Publication Statistics
PubMed Score 149.27
PubMed score by year
PubTator Score 22.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title