SUPT20H
Transcription factor SPT20 homolog
Protein Summary
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.
- ENST00000350612
- ENSP00000218894
- ENSG00000102710
- ENST00000356185
- ENSP00000348512
- ENST00000360252
- ENSP00000353388
- ENST00000464744
- ENSP00000419754
- ENST00000475892
- ENSP00000417510
- C13orf19
- FAM48A
- C13
- FP757
- P38IP
- SPT20
- FAM48A
- C13orf19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.8 | ||
histone modification site profile | 0.67 | ||
hub protein | 0.67 | ||
tissue | 0.62 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 326.61 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 326.61 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0