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Tbio
SUPT16H
FACT complex subunit SPT16

Protein Summary
Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216297
  • ENSP00000216297
  • ENSG00000092201

Symbol
  • FACT140
  • FACTP140
  • CDC68
  • SPT16
  • FACTP140
  • SPT16/CDC68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.94
transcription factor perturbation
0.84
histone modification site profile
0.83
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.7   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.7   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999989719
p_ni:  0.000010281
Score:  0.752
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.999989518
p_ni:  0.000010482
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999988776
p_ni:  0.000011224
Score:  0.9
Data Source:  BioPlex,STRINGDB
MACROD1
Tchem
Family:  Enzyme
Novelty:  0.03610474
p_int:  0.999636243
p_ni:  0.000363757
Score:  0.583
Data Source:  BioPlex,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.999137156
p_ni:  0.000862844
Score:  0.812
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.998783508
p_ni:  0.001216493
Score:  0.787
Data Source:  BioPlex,STRINGDB
CHD1L
Tbio
Family:  Enzyme
Novelty:  0.00980287
p_int:  0.99822298
p_ni:  0.00177702
Score:  0.897
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.997753583
p_ni:  0.002246417
Score:  0.485
Data Source:  BioPlex,STRINGDB
XPC
Tbio
Novelty:  0.00775175
p_int:  0.997377701
p_ni:  0.002622299
Score:  0.848
Data Source:  BioPlex,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.996647744
p_ni:  0.003352256
Score:  0.803
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
82.4
educational attainment
1
1
1
64.3
appendicular lean mass
1
1
1
62.1
calcium measurement
2
2
2
61
self reported educational attainment
1
1
1
48.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
82.4
educational attainment
1
64.3
appendicular lean mass
1
62.1
calcium measurement
2
61
self reported educational attainment
1
48.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPT16 homolog, facilitates chromatin remodeling subunit
VGNC:6771
473332
Macaque
SPT16 homolog, facilitates chromatin remodeling subunit
708066
Mouse
MGI:1890948
114741
Rat
RGD:1310032
305851
Dog
SPT16 homolog, facilitates chromatin remodeling subunit
VGNC:46989
612874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPT16 homolog, facilitates chromatin remodeling subunit
Macaque
SPT16 homolog, facilitates chromatin remodeling subunit
Mouse
Rat
Dog
SPT16 homolog, facilitates chromatin remodeling subunit
Publication Statistics
PubMed Score 110.70
PubMed score by year
PubTator Score 30.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title