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Tbio
SUOX
Sulfite oxidase, mitochondrial

Protein Summary
Description
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266971
  • ENSP00000266971
  • ENSG00000139531
  • ENST00000356124
  • ENSP00000348440
  • ENST00000394109
  • ENSP00000377668
  • ENST00000394115
  • ENSP00000377674
  • ENST00000548274
  • ENSP00000450245
  • ENST00000550065
  • ENSP00000450264
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.88
virus perturbation
0.85
molecular function
0.7
cell line
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.86   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.86   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
CES3
Tbio
Family:  Enzyme
Novelty:  0.00938734
p_int:  0.999931857
p_ni:  0.000068138
p_wrong:  5e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999679039
p_ni:  0.000304399
p_wrong:  0.000016562
Data Source:  BioPlex
SPANXN3
Tdark
Novelty:  4.06770018
p_int:  0.998971263
p_ni:  0.001028708
p_wrong:  3e-8
Score:  0.513
Data Source:  BioPlex,STRINGDB
CHCHD5
Tbio
Novelty:  0.16304141
p_int:  0.998423675
p_ni:  0.00157602
p_wrong:  3.05e-7
Data Source:  BioPlex
TIMM10
Tbio
Family:  Enzyme
Novelty:  0.02727463
p_int:  0.998270141
p_ni:  0.001578371
p_wrong:  0.000151487
Data Source:  BioPlex
FHOD1
Tbio
Novelty:  0.02593459
p_int:  0.997765189
p_ni:  0.002234811
Score:  0.345
Data Source:  BioPlex,STRINGDB
DNAJC11
Tbio
Novelty:  0.31080011
p_int:  0.985986054
p_ni:  0.014013946
Score:  0.215
Data Source:  BioPlex,STRINGDB
TROAP
Tbio
Novelty:  0.06268103
p_int:  0.975595297
p_ni:  0.024382488
p_wrong:  0.000022215
Score:  0.189
Data Source:  BioPlex,STRINGDB
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
p_int:  0.895002791
p_ni:  0.012089806
p_wrong:  0.092907403
Score:  0.228
Data Source:  BioPlex,STRINGDB
TST
Tchem
Family:  Enzyme
Novelty:  0.00214991
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfide oxidation to sulfate
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfide oxidation to sulfate
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
5
5
3.4
96.8
6
5
0
1.3
95.2
mathematical ability
4
4
4
94.3
8
8
0
1.1
93.5
3
3
0
1.3
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
3.4
96.8
0
1.3
95.2
mathematical ability
4
94.3
0
1.1
93.5
0
1.3
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfite oxidase
VGNC:5608
451978
Mouse
MGI:2446117
211389
Rat
RGD:619994
81805
Dog
sulfite oxidase
VGNC:46988
481103
Horse
sulfite oxidase
VGNC:23762
100059135
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfite oxidase
Mouse
Rat
Dog
sulfite oxidase
Horse
sulfite oxidase
Publication Statistics
PubMed Score 100.86
PubMed score by year
PubTator Score 130.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title