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Tbio
SUMO4
Small ubiquitin-related modifier 4

Protein Summary
Description
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326669
  • ENSP00000318635
  • ENSG00000177688

Symbol
  • SMT3H4
  • IDDM5
  • SMT3H4
  • SUMO-4
  • dJ281H8.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.68
cell type or tissue
0.67
hub protein
0.67
protein domain
0.58
tissue sample
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.69   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.69   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.993
Data Source:  STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
Score:  0.959
Data Source:  STRINGDB
SENP1
Tchem
Family:  Enzyme
Novelty:  0.00831213
Score:  0.954
Data Source:  STRINGDB
SAE1
Tbio
Novelty:  0.01613881
Score:  0.951
Data Source:  STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
Score:  0.948
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.914
Data Source:  STRINGDB
SENP6
Tchem
Family:  Enzyme
Novelty:  0.00776149
Score:  0.895
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.84
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.829
Data Source:  STRINGDB
RNF4
Tbio
Family:  Enzyme
Novelty:  0.0119054
Score:  0.82
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
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1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
1
1
0
1.2
68.8
eosinophil count
2
2
2
58.2
eosinophil percentage of leukocytes
1
1
1
49.5
1
1
0
1
31.4
BMI-adjusted hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.2
68.8
eosinophil count
2
58.2
eosinophil percentage of leukocytes
1
49.5
0
1
31.4
BMI-adjusted hip circumference
1
21.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 63.69
PubMed score by year
PubTator Score 63.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title