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Tbio
SUMO1
Small ubiquitin-related modifier 1

Protein Summary
Description
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392244
  • ENSP00000376075
  • ENSG00000116030
  • ENST00000392245
  • ENSP00000376076
  • ENST00000392246
  • ENSP00000376077

Symbol
  • SMT3C
  • SMT3H3
  • UBL1
  • DAP1
  • GMP1
  • PIC1
  • SMT3
  • UBL1
  • OFC10
  • SENP2
  • SMT3C
  • SMT3H3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
kinase perturbation
1
disease perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.98   (req: < 5)
Gene RIFs: 212   (req: <= 3)
Antibodies: 1072   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.98   (req: >= 5)
Gene RIFs: 212   (req: > 3)
Antibodies: 1072   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (540)
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.999
Data Source:  Reactome,STRINGDB
SAE1
Tbio
Novelty:  0.01613881
Score:  0.999
Data Source:  Reactome,STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.999
Data Source:  Reactome,STRINGDB
SENP1
Tchem
Family:  Enzyme
Novelty:  0.00831213
Score:  0.999
Data Source:  Reactome,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
Score:  0.999
Data Source:  Reactome,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
Score:  0.999
Data Source:  Reactome,STRINGDB
RANGAP1
Tbio
Family:  Enzyme
Novelty:  0.00917672
Score:  0.998
Data Source:  Reactome,STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.997
Data Source:  Reactome,STRINGDB
TDG
Tbio
Family:  Enzyme
Novelty:  0.00283178
Score:  0.996
Data Source:  Reactome,STRINGDB
SENP2
Tbio
Family:  Enzyme
Novelty:  0.17238834
Score:  0.995
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (71)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cytokine Signaling in Immune system
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cytokine Signaling in Immune system
DNA Double Strand Break Response
DNA Double-Strand Break Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (52)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
61
C-reactive protein measurement
1
1
1
35
triglyceride measurement
1
1
1
31.4
apolipoprotein B measurement
1
1
1
27.2
low density lipoprotein cholesterol measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
61
C-reactive protein measurement
1
35
triglyceride measurement
1
31.4
apolipoprotein B measurement
1
27.2
low density lipoprotein cholesterol measurement
1
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
small ubiquitin-like modifier 1
703644
Mouse
MGI:1197010
22218
Rat
RGD:1306919
301442
Dog
small ubiquitin-like modifier 1
478874
Horse
small ubiquitin-like modifier 1
VGNC:51492
100067107
Species
Name
OMA
EggNOG
Inparanoid
Macaque
small ubiquitin-like modifier 1
Mouse
Rat
Dog
small ubiquitin-like modifier 1
Horse
small ubiquitin-like modifier 1
Publication Statistics
PubMed Score 746.98
PubMed score by year
PubTator Score 491.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title