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Tbio
SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

Protein Summary
Description
Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
transcription factor binding site profile
0.73
transcription factor
0.71
kinase perturbation
0.66
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
APOD
Tbio
Novelty:  0.0031899
p_int:  0.98870425
p_ni:  0.01129575
Score:  0.295
Data Source:  BioPlex,STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.982168153
p_ni:  0.017831847
Score:  0.936
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.966489865
p_ni:  0.033510135
Score:  0.228
Data Source:  BioPlex,STRINGDB
ARSH
Tbio
Family:  Enzyme
Novelty:  0.03202479
Score:  0.966
Data Source:  STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
Score:  0.957
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.953
Data Source:  STRINGDB
ARSI
Tbio
Family:  Enzyme
Novelty:  0.04002595
Score:  0.952
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.951
Data Source:  STRINGDB
ARSD
Tbio
Family:  Enzyme
Novelty:  0.00680724
Score:  0.951
Data Source:  STRINGDB
ARSJ
Tdark
Family:  Enzyme
Novelty:  0.00769596
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
12
21
94.5
glycine measurement
3
2
3
90.8
lymphocyte count
2
2
2
86.1
blood metabolite measurement
2
1
2
69.8
myeloid white cell count
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
21
94.5
glycine measurement
3
90.8
lymphocyte count
2
86.1
blood metabolite measurement
2
69.8
myeloid white cell count
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfatase modifying factor 2
VGNC:4526
742768
Macaque
sulfatase modifying factor 2
715253
Mouse
MGI:1915152
67902
Rat
RGD:1563253
360800
Dog
sulfatase modifying factor 2
VGNC:46983
479701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfatase modifying factor 2
Macaque
sulfatase modifying factor 2
Mouse
Rat
Dog
sulfatase modifying factor 2
Publication Statistics
PubMed Score 12.71
PubMed score by year
PubTator Score 465.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title