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Tbio
SULT4A1
Sulfotransferase 4A1

Protein Summary
Description
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330884
  • ENSP00000332565
  • ENSG00000130540
  • ENST00000422525
  • ENSP00000388285

Symbol
  • SULTX3
  • NST
  • BRSTL1
  • SULTX3
  • BR-STL-1
  • DJ388M5.3
  • hBR-STL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cell type or tissue
0.65
small molecule perturbation
0.65
tissue
0.62
gene perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.25   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.25   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
BCL6B
Tbio
Family:  TF
Novelty:  0.0439906
p_int:  0.999983152
p_ni:  0.000016792
p_wrong:  5.6e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
PARVG
Tbio
Novelty:  0.08921402
p_int:  0.99901204
p_ni:  0.000987804
p_wrong:  1.57e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
p_int:  0.993795607
p_ni:  0.006204393
Score:  0.848
Data Source:  BioPlex,STRINGDB
ERMN
Tbio
Novelty:  0.05302803
p_int:  0.977977322
p_ni:  0.022016576
p_wrong:  0.000006101
Score:  0.722
Data Source:  BioPlex,STRINGDB
SULT1A3
Tbio
Family:  Enzyme
Novelty:  0.00335383
p_int:  0.962489206
p_ni:  0.037510794
Score:  0.845
Data Source:  BioPlex,STRINGDB
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
Score:  0.932
Data Source:  STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
Score:  0.792
Data Source:  STRINGDB
NDRG4
Tbio
Novelty:  0.01974969
Score:  0.755
Data Source:  STRINGDB
PDZRN4
Tdark
Novelty:  0.1881035
Score:  0.726
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
5
4
8
37.7
98.8
serum alanine aminotransferase measurement
8
4
8
6
98.8
liver fibrosis measurement
3
3
9
96.7
7
3
1
1.8
95.8
hemoglobin measurement
4
3
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
8
37.7
98.8
serum alanine aminotransferase measurement
8
6
98.8
liver fibrosis measurement
9
96.7
1
1.8
95.8
hemoglobin measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 4A member 1
VGNC:6159
458894
Macaque
sulfotransferase family 4A member 1
100428737
Mouse
MGI:1888971
29859
Rat
RGD:69292
58953
Dog
sulfotransferase family 4A member 1
VGNC:46980
609410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 4A member 1
Macaque
sulfotransferase family 4A member 1
Mouse
Rat
Dog
sulfotransferase family 4A member 1
Publication Statistics
PubMed Score 42.25
PubMed score by year
PubTator Score 28.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title