Tbio SULT4A1 Sulfotransferase 4A1

Protein Summary

Description

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BR01
• B2R7N3
• O43728
• ST4A1

Gene Name

• SULT4A1

Ensembl ID

• ENST00000330884
• ENSP00000332565
• ENSG00000130540
• ENST00000422525
• ENSP00000388285

Symbol

• SULTX3
• NST
• BRSTL1
• SULTX3
• BR-STL-1
• DJ388M5.3
• hBR-STL-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
cell type or tissue	0.65
small molecule perturbation	0.65
tissue	0.62
gene perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.53   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.53   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0