SULT1C4
Sulfotransferase 1C4
Protein Summary
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]
- ENST00000272452
- ENSP00000272452
- ENSG00000198075
- ENST00000409309
- ENSP00000387225
- SULT1C2
- SULT1C
- SULT1C2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.56 | ||
histone modification site profile | 0.45 | ||
pathway | 0.44 | ||
tissue sample | 0.42 | ||
chemical | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.46 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.46 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0