Tbio SULT1A3 Sulfotransferase 1A3

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P0DMM9
• B4DNV0
• O95603
• P50224
• Q1ET66
• Q6ZWJ5
• ST1A3

Gene Name

• SULT1A3

Ensembl ID

• ENST00000338971
• ENSP00000343645
• ENSG00000261052
• ENST00000395138
• ENSP00000378570
• ENST00000563322
• ENSP00000454518

Symbol

• STM
• STM
• HAST
• HAST3
• M-PST
• ST1A3
• ST1A4
• ST1A5
• TL-PST
• ST1A3/ST1A4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.77
tissue	0.6
tissue sample	0.6
cell line	0.5
pathway	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.17   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.17   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

SULT1A2

Tbio

Family:  Enzyme

Novelty:  0.01102416

p_int:  0.999999993

p_ni:  6e-9

p_wrong:  1e-9

Score:  0.868

Data Source:  BioPlex,STRINGDB

SULT1A1

Tchem

Family:  Enzyme

Novelty:  0.00238409

p_int:  0.99999998

p_ni:  2e-8

Score:  0.934

Data Source:  BioPlex,STRINGDB

MPPED2

Tbio

Family:  Enzyme

Novelty:  0.091909

p_int:  0.987699154

p_ni:  0.012300846

Score:  0.393

Data Source:  BioPlex,STRINGDB

SULT4A1

Tbio

Family:  Enzyme

Novelty:  0.02455678

p_int:  0.962489206

p_ni:  0.037510794

Score:  0.845

Data Source:  BioPlex,STRINGDB

SULT1C2

Tbio

Family:  Enzyme

Novelty:  0.02956075

p_int:  0.905795058

p_ni:  0.094204942

Score:  0.879

Data Source:  BioPlex,STRINGDB

TTC1

Tbio

Novelty:  0.01389711

p_int:  0.777117227

p_ni:  0.222882772

p_wrong:  1e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

THBD

Tbio

Novelty:  0.00039359

Score:  0.84

Data Source:  STRINGDB

SULT1A4

Tdark

Family:  Enzyme

Novelty:  1.36001222

Score:  0.819

Data Source:  STRINGDB

GOT1

Tbio

Family:  Enzyme

Novelty:  0.00448817

Score:  0.74

Data Source:  STRINGDB

VWF

Tclin

Novelty:  0.00009007

Score:  0.635

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (8)

KEGG (1)

PathwayCommons (2)

Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Cytosolic sulfonation of small molecules	24 targets	R-HSA-156584
Reactome	IRE1alpha activates chaperones	50 targets	R-HSA-381070
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Cytosolic sulfonation of small molecules	24 targets	R-HSA-156584
IRE1alpha activates chaperones	50 targets	R-HSA-381070
Metabolism	2112 targets	R-HSA-1430728
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (4)

Components (1)

Processes (14)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
amine sulfotransferase activity	Inferred from Direct Assay (IDA)	CAFA
sulfate binding	Inferred from Direct Assay (IDA)	CAFA
sulfotransferase activity	Inferred from Direct Assay (IDA)	BHF-UCL
aryl sulfotransferase activity	Inferred from Mutant Phenotype (IMP)	CACAO

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1	1	1		34.9
diastolic blood pressure	EFO_0006336	1	1	1		14.1
multiple sclerosis	EFO_0003885	1	1	0	1.1	9.3
Hodgkins lymphoma	EFO_0000183	1	1	0	1.2	0.2
tonsillectomy risk measurement	EFO_0007924	1	1	0	1.1	0.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1		34.9
diastolic blood pressure	EFO_0006336	1		14.1
multiple sclerosis	EFO_0003885	0	1.1	9.3
Hodgkins lymphoma	EFO_0000183	0	1.2	0.2
tonsillectomy risk measurement	EFO_0007924	0	1.1	0.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Catecholamine metabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid metabolism
Polymorphism
Reference proteome
Steroid metabolism

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
diastolic blood pressure
Hodgkins lymphoma
multiple sclerosis
tonsillectomy risk measurement

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3		100428398
Mouse	sulfotransferase family 1A, phenol-preferring, member 1	MGI:102896	20887
Rat	sulfotransferase family 1A member 1	RGD:3767	83783
Cow	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1		282485
Opossum	sulfotransferase 1A1		100013048

Species	Name	OMA	EggNOG	Inparanoid
Macaque	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Mouse	sulfotransferase family 1A, phenol-preferring, member 1
Rat	sulfotransferase family 1A member 1
Cow	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Opossum	sulfotransferase 1A1

Publication Statistics

PubMed Score 336.17

PubMed score by year

Reset Zoom

PubTator Score 791.88

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (63)

GeneRif Annotations (25)

Items per page:

10

0 of 0

PMID	Year	Title