Tbio SUGT1 Protein SGT1 homolog

Protein Summary

Description

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9Y2Z0
• A2A303
• Q5JAK5
• Q5TAM6
• Q6VXY6

Gene Name

• SUGT1

Ensembl ID

• ENST00000310528
• ENSP00000308067
• ENSG00000165416
• ENST00000343788
• ENSP00000367208

Symbol

• SGT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
interacting protein	0.95
disease perturbation	0.93
histone modification site profile	0.9
transcription factor binding site profile	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.71   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0