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Tbio
SUGP1
SURP and G-patch domain-containing protein 1

Protein Summary
Description
Plays a role in pre-mRNA splicing. SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247001
  • ENSP00000247001
  • ENSG00000105705
  • ENST00000588731
  • ENSP00000465413

Symbol
  • SF4
  • RBP
  • SF4
  • F23858
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.89
trait
0.75
transcription factor binding site profile
0.73
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.67   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.67   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (250)
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.999958669
p_ni:  0.000041323
p_wrong:  8e-9
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.999784689
p_ni:  0.000215256
p_wrong:  5.5e-8
Data Source:  BioPlex
DUSP23
Tbio
Family:  Enzyme
Novelty:  0.06522366
p_int:  0.998391354
p_ni:  0.001608646
Score:  0.167
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.992982998
p_ni:  0.006989475
p_wrong:  0.000027527
Score:  0.904
Data Source:  BioPlex,STRINGDB
PLK2
Tchem
Family:  Kinase
Novelty:  0.00750465
p_int:  0.988713436
p_ni:  0.01128656
p_wrong:  4e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
CTPS2
Tbio
Family:  Enzyme
Novelty:  0.06147923
p_int:  0.961447148
p_ni:  0.038552852
Score:  0.345
Data Source:  BioPlex,STRINGDB
ACBD7
Tdark
Novelty:  0.32019061
p_int:  0.946151177
p_ni:  0.053783139
p_wrong:  0.000065685
Score:  0.157
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.944762416
p_ni:  0.050606589
p_wrong:  0.004630995
Score:  0.263
Data Source:  BioPlex,STRINGDB
FAM177A1
Tdark
Novelty:  0.31314275
p_int:  0.944762416
p_ni:  0.050606589
p_wrong:  0.004630995
Data Source:  BioPlex
CDK17
Tchem
Family:  Kinase
Novelty:  0.25046297
p_int:  0.944295096
p_ni:  0.0557045
p_wrong:  4.05e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
11
20
3.8
99.8
triglyceride measurement
18
10
28
8.2
99.6
total cholesterol measurement
9
6
13
4.4
99.4
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
4
4
17.9
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
20
3.8
99.8
triglyceride measurement
28
8.2
99.6
total cholesterol measurement
13
4.4
99.4
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
4
17.9
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SURP and G-patch domain containing 1
VGNC:2239
455874
Macaque
SURP and G-patch domain containing 1
719772
Mouse
MGI:1917866
70616
Rat
RGD:1310496
290666
Dog
SURP and G-patch domain containing 1
VGNC:46972
476661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SURP and G-patch domain containing 1
Macaque
SURP and G-patch domain containing 1
Mouse
Rat
Dog
SURP and G-patch domain containing 1
Publication Statistics
PubMed Score 228.67
PubMed score by year
PubTator Score 191.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title