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Tbio
SUDS3
Sin3 histone deacetylase corepressor complex component SDS3

Protein Summary
Description
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543473
  • ENSP00000443988
  • ENSG00000111707

Symbol
  • SAP45
  • SDS3
  • SDS3
  • SAP45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor perturbation
0.84
kinase perturbation
0.81
transcription factor binding site profile
0.79
biological process
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.913
Data Source:  BioPlex,STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
p_int:  0.999999817
p_ni:  1.83e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.9999998
p_ni:  2e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.971
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999998699
p_ni:  0.000001301
Score:  0.985
Data Source:  BioPlex,STRINGDB
ZNF704
Tdark
Novelty:  0.34442716
p_int:  0.999844561
p_ni:  0.000155439
Score:  0.803
Data Source:  BioPlex,STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
p_int:  0.999787348
p_ni:  0.000212649
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
p_int:  0.999534269
p_ni:  0.000465731
Score:  0.641
Data Source:  BioPlex,STRINGDB
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
p_int:  0.998273434
p_ni:  0.001726566
Score:  0.711
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.995492483
p_ni:  0.004507517
Score:  0.515
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
2
2
6.3
58.9
wellbeing measurement
1
1
1
40.7
depressive symptom measurement
1
1
1
33.1
loneliness measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
6.3
58.9
wellbeing measurement
1
40.7
depressive symptom measurement
1
33.1
loneliness measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SDS3 homolog, SIN3A corepressor complex component
VGNC:5607
452293
Macaque
SDS3 homolog, SIN3A corepressor complex component
696166
Mouse
MGI:1919204
71954
Rat
RGD:1305986
360819
Dog
SDS3 homolog, SIN3A corepressor complex component
VGNC:46970
100856145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SDS3 homolog, SIN3A corepressor complex component
Macaque
SDS3 homolog, SIN3A corepressor complex component
Mouse
Rat
Dog
SDS3 homolog, SIN3A corepressor complex component
Publication Statistics
PubMed Score 24.53
PubMed score by year
PubTator Score 15.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title