You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SUCLG1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Protein Summary
Description
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393868
  • ENSP00000377446
  • ENSG00000163541

Symbol
  • GALPHA
  • MTDPS9
  • SUCLA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.97
protein domain
0.85
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.72   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.72   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (289)
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
p_int:  0.999999561
p_ni:  4.39e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SUCLG2
Tbio
Family:  Enzyme
Novelty:  0.00094061
p_int:  0.999476209
p_ni:  0.000523791
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AARS2
Tbio
Family:  Enzyme
Novelty:  0.01309387
p_int:  0.99855023
p_ni:  0.00144977
Score:  0.282
Data Source:  BioPlex,STRINGDB
POLR3C
Tbio
Family:  Enzyme
Novelty:  0.05778457
p_int:  0.975798815
p_ni:  0.024201183
p_wrong:  3e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
p_int:  0.941102237
p_ni:  0.058897763
Score:  0.518
Data Source:  BioPlex,STRINGDB
LARS2
Tbio
Family:  Enzyme
Novelty:  0.00543895
p_int:  0.81168498
p_ni:  0.18831502
Score:  0.214
Data Source:  BioPlex,STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.998
Data Source:  STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
Score:  0.996
Data Source:  STRINGDB
DLST
Tbio
Family:  Enzyme
Novelty:  0.01516932
Score:  0.995
Data Source:  STRINGDB
SDHC
Tbio
Family:  Enzyme
Novelty:  0.0005776
Score:  0.99
Data Source:  STRINGDB
Pathways (14)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
succinate-CoA ligase alpha subunit
VGNC:10285
470417
Macaque
succinate-CoA ligase alpha subunit
693991
Mouse
MGI:1927234
56451
Rat
RGD:619821
114597
Dog
succinate-CoA ligase alpha subunit
VGNC:46966
475775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
succinate-CoA ligase alpha subunit
Macaque
succinate-CoA ligase alpha subunit
Mouse
Rat
Dog
succinate-CoA ligase alpha subunit
Publication Statistics
PubMed Score 79.72
PubMed score by year
PubTator Score 400.69
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title