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Tbio
STXBP5L
Syntaxin-binding protein 5-like

Protein Summary
Description
May play a role in vesicle trafficking and exocytosis. The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273666
  • ENSP00000273666
  • ENSG00000145087
  • ENST00000461772
  • ENSP00000420642

Symbol
  • KIAA1006
  • LLGL4
  • LLGL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.84
disease perturbation
0.74
virus perturbation
0.72
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
STX19
Tdark
Novelty:  0.99387951
p_int:  0.999942315
p_ni:  1.21e-7
p_wrong:  0.000057564
Score:  0.587
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.913
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.879
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.851
Data Source:  STRINGDB
KHDRBS2
Tbio
Novelty:  0.01986638
Score:  0.73
Data Source:  STRINGDB
KHDRBS1
Tbio
Novelty:  0.00647929
Score:  0.711
Data Source:  STRINGDB
THOC7
Tbio
Novelty:  0.16971494
Score:  0.706
Data Source:  STRINGDB
OSBPL2
Tbio
Novelty:  0.03946704
Score:  0.698
Data Source:  STRINGDB
SGCE
Tbio
Novelty:  0.00449577
Score:  0.674
Data Source:  STRINGDB
IP6K2
Tbio
Family:  Kinase
Novelty:  0.05004446
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
4
4
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
4
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 5 like
VGNC:2597
460617
Macaque
syntaxin binding protein 5 like
100423442
Mouse
MGI:2443815
207227
Rat
RGD:1311561
288080
Dog
syntaxin binding protein 5 like
VGNC:46964
100684760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 5 like
Macaque
syntaxin binding protein 5 like
Mouse
Rat
Dog
syntaxin binding protein 5 like
Publication Statistics
PubMed Score 8.32
PubMed score by year
PubTator Score 3.62
PubTator score by year
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Related Publications
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PMID
Year
Title