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Tbio
STXBP5
Syntaxin-binding protein 5

Protein Summary
Description
Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321680
  • ENSP00000321826
  • ENSG00000164506
  • ENST00000367480
  • ENSP00000356450
  • ENST00000367481
  • ENSP00000356451

Symbol
  • LLGL3
  • LGL3
  • LLGL3
  • Nbla04300
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.73
cell line
0.68
cellular component
0.66
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.77   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.77   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999999975
p_ni:  2.4e-8
p_wrong:  1e-9
Score:  0.736
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999999851
p_ni:  1.48e-7
Score:  0.853
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.808
Data Source:  BioPlex,STRINGDB
STX3
Tbio
Novelty:  0.01055819
p_int:  0.999999806
p_ni:  1.94e-7
Score:  0.844
Data Source:  BioPlex,STRINGDB
STX19
Tdark
Novelty:  0.99387951
p_int:  0.999997829
p_ni:  0.000002162
p_wrong:  9e-9
Score:  0.418
Data Source:  BioPlex,STRINGDB
STX6
Tbio
Novelty:  0.01494028
p_int:  0.999865309
p_ni:  0.000134673
p_wrong:  1.8e-8
Score:  0.855
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.999765437
p_ni:  0.000234545
p_wrong:  1.9e-8
Score:  0.785
Data Source:  BioPlex,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.998487232
p_ni:  0.001450431
p_wrong:  0.000062337
Score:  0.835
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.971
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
3
3
2
3
94.8
factor VIII measurement
1
2
3
76.7
neutrophil count
2
1
2
72.6
mean platelet volume
2
2
2
71.4
myeloid white cell count
1
1
1
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
3
94.8
factor VIII measurement
3
76.7
neutrophil count
2
72.6
mean platelet volume
2
71.4
myeloid white cell count
1
67.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 5
VGNC:7931
463053
Macaque
syntaxin binding protein 5
701629
Mouse
MGI:1926058
78808
Rat
RGD:708517
81022
Dog
syntaxin binding protein 5
VGNC:46963
476237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 5
Macaque
syntaxin binding protein 5
Mouse
Rat
Dog
syntaxin binding protein 5
Publication Statistics
PubMed Score 64.77
PubMed score by year
PubTator Score 30.18
PubTator score by year
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Related Publications
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PMID
Year
Title