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Tbio
STXBP4
Syntaxin-binding protein 4

Protein Summary
Description
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376352
  • ENSP00000365530
  • ENSG00000166263
  • ENST00000398391
  • ENSP00000381427

Symbol
  • Synip
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.91
trait
0.75
transcription factor binding site profile
0.69
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.75   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.99999917
p_ni:  8.3e-7
Score:  0.43
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999997799
p_ni:  0.000002201
Data Source:  BioPlex
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999994391
p_ni:  0.000005609
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.999993427
p_ni:  0.000006573
Data Source:  BioPlex
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.99999327
p_ni:  0.00000673
Score:  0.183
Data Source:  BioPlex,STRINGDB
SUSD6
Tbio
Novelty:  0.08836898
p_int:  0.999988863
p_ni:  0.000011137
Score:  0.261
Data Source:  BioPlex,STRINGDB
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.999904527
p_ni:  0.000095473
Score:  0.154
Data Source:  BioPlex,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.999845072
p_ni:  0.000154928
p_wrong:  1e-9
Data Source:  BioPlex
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.999631532
p_ni:  0.000368468
Score:  0.151
Data Source:  BioPlex,STRINGDB
FNDC11
Tdark
Novelty:  20.00979352
p_int:  0.999515552
p_ni:  0.000484448
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated transcriptional targets of deltaNp63 isoforms
PathwayCommons: pid
Insulin-mediated glucose transport
Name
Explore in Pharos
Explore in Source
Validated transcriptional targets of deltaNp63 isoforms
Insulin-mediated glucose transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
1
1.1
77.8
1
1
1
66
1
1
1
66
platelet crit
1
1
1
63.4
red blood cell density measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
77.8
1
66
1
66
platelet crit
1
63.4
red blood cell density measurement
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 4
VGNC:9665
468411
Macaque
syntaxin binding protein 4
706062
Mouse
MGI:1342296
20913
Rat
RGD:1307903
303443
Dog
syntaxin binding protein 4
VGNC:46962
491094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 4
Macaque
syntaxin binding protein 4
Mouse
Rat
Dog
syntaxin binding protein 4
Publication Statistics
PubMed Score 12.75
PubMed score by year
PubTator Score 7.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title