Tbio STXBP2 Syntaxin-binding protein 2

Protein Summary

Description

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q15833
• B4E175
• E7EQD5
• Q9BU65

Gene Name

• STXBP2

Ensembl ID

• ENST00000221283
• ENSP00000221283
• ENSG00000076944
• ENST00000414284
• ENSP00000409471
• ENST00000441779
• ENSP00000413606

Symbol

• UNC18B
• FHL5
• UNC18B
• Hunc18b
• UNC18-2
• pp10122
• MUNC18-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
kinase perturbation	0.84
transcription factor perturbation	0.84
cellular component	0.7
gene perturbation	0.63

Protein Classes

PANTHER Classes

Protein / Transporter / Syntaxin-binding Protein 2

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 2

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0