Tbio STX8 Syntaxin-8

Protein Summary

Description

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9UNK0
• O60712
• Q53XT8

Gene Name

• STX8

Ensembl ID

• ENST00000306357
• ENSP00000305255
• ENSG00000170310

Symbol

• CARB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
histone modification site profile	0.91
cellular component	0.9
disease perturbation	0.83
trait	0.75

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-8

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.88   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.88   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (128)

Explore Interacting Targets

1 – 10 of 128

• See Interactions on String-DB

TMEM63C

Tdark

Family:  IC

Novelty:  0.02849254

p_int:  0.99998591

p_ni:  0.00001409

Data Source:  BioPlex

STX7

Tbio

Novelty:  0.03109969

p_int:  0.999955042

p_ni:  0.000044957

Score:  0.996

Data Source:  BioPlex,STRINGDB

NAPG

Tbio

Novelty:  0.02295985

p_int:  0.999877887

p_ni:  0.000122113

Score:  0.943

Data Source:  BioPlex,STRINGDB

STX18

Tbio

Novelty:  0.0259034

p_int:  0.999778585

p_ni:  0.000221415

Score:  0.938

Data Source:  BioPlex,STRINGDB

STX12

Tbio

Novelty:  0.03836262

p_int:  0.999681865

p_ni:  0.000318135

Score:  0.956

Data Source:  BioPlex,STRINGDB

FAM9C

Tdark

Novelty:  0.86727989

p_int:  0.999301562

p_ni:  0.000698438

Data Source:  BioPlex

SEC22B

Tbio

Novelty:  0.03035448

p_int:  0.999120065

p_ni:  0.000879935

Score:  0.92

Data Source:  BioPlex,STRINGDB

VAMP4

Tbio

Novelty:  0.02949854

p_int:  0.998747481

p_ni:  0.001252519

Score:  0.929

Data Source:  BioPlex,STRINGDB

DTNBP1

Tbio

Novelty:  0.00341619

p_int:  0.998123306

p_ni:  0.001876694

Score:  0.343

Data Source:  BioPlex,STRINGDB

VAMP5

Tbio

Novelty:  0.09958312

p_int:  0.998048122

p_ni:  0.001951878

Score:  0.844

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	SNARE interactions in vesicular transport	34 targets	path:hsa04130

Name	Explore in Pharos	Explore in Source
SNARE interactions in vesicular transport	34 targets	path:hsa04130

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (5)

Components (16)

Processes (7)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
chloride channel inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
syntaxin binding	Inferred from Physical Interaction (IPI)	UniProtKB
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ubiquitin protein ligase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	1	3		81.7
atypical femoral fracture	EFO_0009960	1	1	0	7.4	17.8
response to bisphosphonate	EFO_0009958	1	1	0	7.4	17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		81.7
atypical femoral fracture	EFO_0009960	0	7.4	17.8
response to bisphosphonate	EFO_0009958	0	7.4	17.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
atypical femoral fracture
heel bone mineral density
response to bisphosphonate

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntaxin 8	VGNC:9666	455082
Macaque	syntaxin 8		717678
Mouse	syntaxin 8	MGI:1890156	55943
Rat	syntaxin 8	RGD:61917	59074
Dog	syntaxin 8	VGNC:53452	479499

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntaxin 8
Macaque	syntaxin 8
Mouse	syntaxin 8
Rat	syntaxin 8
Dog	syntaxin 8

Publication Statistics

PubMed Score 93.88

PubMed score by year

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PubTator Score 287.41

PubTator score by year

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Related Publications

Text Mined References (28)

GeneRif Annotations (15)

Items per page:

10

0 of 0

PMID	Year	Title