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Tbio
STX8
Syntaxin-8

Protein Summary
Description
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306357
  • ENSP00000305255
  • ENSG00000170310

Symbol
  • CARB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.91
cellular component
0.9
disease perturbation
0.83
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.88   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.88   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.99998591
p_ni:  0.00001409
Data Source:  BioPlex
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999955042
p_ni:  0.000044957
Score:  0.996
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.999877887
p_ni:  0.000122113
Score:  0.943
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999778585
p_ni:  0.000221415
Score:  0.938
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999681865
p_ni:  0.000318135
Score:  0.956
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999301562
p_ni:  0.000698438
Data Source:  BioPlex
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999120065
p_ni:  0.000879935
Score:  0.92
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.998747481
p_ni:  0.001252519
Score:  0.929
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.998123306
p_ni:  0.001876694
Score:  0.343
Data Source:  BioPlex,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.998048122
p_ni:  0.001951878
Score:  0.844
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
81.7
atypical femoral fracture
1
1
0
7.4
17.8
response to bisphosphonate
1
1
0
7.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
81.7
atypical femoral fracture
0
7.4
17.8
response to bisphosphonate
0
7.4
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 8
VGNC:9666
455082
Macaque
syntaxin 8
717678
Mouse
MGI:1890156
55943
Rat
RGD:61917
59074
Dog
syntaxin 8
VGNC:53452
479499
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 8
Macaque
syntaxin 8
Mouse
Rat
Dog
syntaxin 8
Publication Statistics
PubMed Score 93.88
PubMed score by year
PubTator Score 287.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title