Protein Summary
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER. The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
- ENST00000306357
- ENSP00000305255
- ENSG00000170310
- CARB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.96 | ||
histone modification site profile | 0.91 | ||
cellular component | 0.9 | ||
disease perturbation | 0.83 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.88 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 93.88 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
STX7
Novelty: 0.03109969
p_int: 0.999955042
p_ni: 0.000044957
Score: 0.996
Data Source: BioPlex,STRINGDB
NAPG
Novelty: 0.02295985
p_int: 0.999877887
p_ni: 0.000122113
Score: 0.943
Data Source: BioPlex,STRINGDB
STX18
Novelty: 0.0259034
p_int: 0.999778585
p_ni: 0.000221415
Score: 0.938
Data Source: BioPlex,STRINGDB
STX12
Novelty: 0.03836262
p_int: 0.999681865
p_ni: 0.000318135
Score: 0.956
Data Source: BioPlex,STRINGDB
SEC22B
Novelty: 0.03035448
p_int: 0.999120065
p_ni: 0.000879935
Score: 0.92
Data Source: BioPlex,STRINGDB
VAMP4
Novelty: 0.02949854
p_int: 0.998747481
p_ni: 0.001252519
Score: 0.929
Data Source: BioPlex,STRINGDB
DTNBP1
Novelty: 0.00341619
p_int: 0.998123306
p_ni: 0.001876694
Score: 0.343
Data Source: BioPlex,STRINGDB
VAMP5
Novelty: 0.09958312
p_int: 0.998048122
p_ni: 0.001951878
Score: 0.844
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | SNARE interactions in vesicular transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
SNARE interactions in vesicular transport | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (5)
Components (16)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 1 | 3 | 81.7 | |||||
atypical femoral fracture | 1 | 1 | 0 | 7.4 | 17.8 | ||||
response to bisphosphonate | 1 | 1 | 0 | 7.4 | 17.8 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 81.7 | |||||
atypical femoral fracture | 0 | 7.4 | 17.8 | ||||
response to bisphosphonate | 0 | 7.4 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syntaxin 8 | VGNC:9666 | 455082 | |||||
Macaque | syntaxin 8 | 717678 | ||||||
Mouse | MGI:1890156 | 55943 | ||||||
Rat | RGD:61917 | 59074 | ||||||
Dog | syntaxin 8 | VGNC:53452 | 479499 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syntaxin 8 | |||||
Macaque | syntaxin 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 8 | |||||
Publication Statistics
PubMed Score 93.88
PubMed score by year
PubTator Score 287.41
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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