Protein Summary
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]
- ENST00000367937
- ENSP00000356914
- ENSG00000079950
- ENST00000367941
- ENSP00000356918
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
cell type or tissue | 0.83 | ||
transcription factor perturbation | 0.8 | ||
interacting protein | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.71 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 149 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.71 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 149 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (175)
NAPG
Novelty: 0.02295985
p_int: 0.999999996
p_ni: 4e-9
Score: 0.889
Data Source: BioPlex,STRINGDB
STX6
Novelty: 0.01494028
p_int: 0.999999949
p_ni: 5.1e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
VAMP4
Novelty: 0.02949854
p_int: 0.999999916
p_ni: 8.4e-8
Score: 0.956
Data Source: BioPlex,STRINGDB
STXBP5
Novelty: 0.01899802
p_int: 0.999999839
p_ni: 1.61e-7
Score: 0.808
Data Source: BioPlex,STRINGDB
GOSR1
Novelty: 0.03139481
p_int: 0.999999379
p_ni: 6.21e-7
Score: 0.93
Data Source: BioPlex,STRINGDB
VTI1B
Novelty: 0.00955467
p_int: 0.999999148
p_ni: 8.52e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
STXBP6
Novelty: 0.13195671
p_int: 0.999996561
p_ni: 0.000003439
p_wrong: 1e-9
Score: 0.746
Data Source: BioPlex,STRINGDB
ZKSCAN1
Family: TF
Novelty: 0.08190662
p_int: 0.999993234
p_ni: 0.000006765
p_wrong: 1e-9
Score: 0.224
Data Source: BioPlex,STRINGDB
VTI1A
Novelty: 0.04616617
p_int: 0.999988421
p_ni: 0.000011437
p_wrong: 1.42e-7
Score: 0.991
Data Source: BioPlex,STRINGDB
GOSR2
Novelty: 0.02447711
p_int: 0.99998756
p_ni: 0.000012439
Score: 0.904
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
KEGG (2)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Phagosome | ||||
KEGG | SNARE interactions in vesicular transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Phagosome | ||||
SNARE interactions in vesicular transport | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (4)
Components (19)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 2 | 6 | 84.6 | |||||
red blood cell distribution width | 4 | 2 | 4 | 82.4 | |||||
sensory perception of smell | 1 | 1 | 1 | 63.1 | |||||
reticulocyte measurement | 3 | 1 | 3 | 42.3 | |||||
body height | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 84.6 | |||||
red blood cell distribution width | 4 | 82.4 | |||||
sensory perception of smell | 1 | 63.1 | |||||
reticulocyte measurement | 3 | 42.3 | |||||
body height | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syntaxin 7 | VGNC:3714 | 463004 | |||||
Macaque | syntaxin 7 | 709667 | ||||||
Mouse | MGI:1858210 | 53331 | ||||||
Rat | RGD:619747 | 60466 | ||||||
Dog | syntaxin 7 | VGNC:46958 | 483987 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syntaxin 7 | |||||
Macaque | syntaxin 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 7 | |||||
Publication Statistics
PubMed Score 29.71
PubMed score by year
PubTator Score 20.00
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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