Tbio STX7 Syntaxin-7

Protein Summary

Description

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• O15400
• E1P579
• Q5SZW2
• Q96ES9

Gene Name

• STX7

Ensembl ID

• ENST00000367937
• ENSP00000356914
• ENSG00000079950
• ENST00000367941
• ENSP00000356918

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
cell type or tissue	0.83
transcription factor perturbation	0.8
interacting protein	0.79

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-7

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.71   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.71   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (175)

Explore Interacting Targets

1 – 10 of 175

• See Interactions on String-DB

NAPG

Tbio

Novelty:  0.02295985

p_int:  0.999999996

p_ni:  4e-9

Score:  0.889

Data Source:  BioPlex,STRINGDB

STX6

Tbio

Novelty:  0.01494028

p_int:  0.999999949

p_ni:  5.1e-8

Score:  0.981

Data Source:  BioPlex,STRINGDB

VAMP4

Tbio

Novelty:  0.02949854

p_int:  0.999999916

p_ni:  8.4e-8

Score:  0.956

Data Source:  BioPlex,STRINGDB

STXBP5

Tbio

Novelty:  0.01899802

p_int:  0.999999839

p_ni:  1.61e-7

Score:  0.808

Data Source:  BioPlex,STRINGDB

GOSR1

Tbio

Novelty:  0.03139481

p_int:  0.999999379

p_ni:  6.21e-7

Score:  0.93

Data Source:  BioPlex,STRINGDB

VTI1B

Tbio

Novelty:  0.00955467

p_int:  0.999999148

p_ni:  8.52e-7

Score:  0.988

Data Source:  BioPlex,STRINGDB

STXBP6

Tbio

Novelty:  0.13195671

p_int:  0.999996561

p_ni:  0.000003439

p_wrong:  1e-9

Score:  0.746

Data Source:  BioPlex,STRINGDB

ZKSCAN1

Tbio

Family:  TF

Novelty:  0.08190662

p_int:  0.999993234

p_ni:  0.000006765

p_wrong:  1e-9

Score:  0.224

Data Source:  BioPlex,STRINGDB

VTI1A

Tbio

Novelty:  0.04616617

p_int:  0.999988421

p_ni:  0.000011437

p_wrong:  1.42e-7

Score:  0.991

Data Source:  BioPlex,STRINGDB

GOSR2

Tbio

Novelty:  0.02447711

p_int:  0.99998756

p_ni:  0.000012439

Score:  0.904

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

KEGG (2)

PathwayCommons (2)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Phagosome	230 targets	path:hsa04145
KEGG	SNARE interactions in vesicular transport	34 targets	path:hsa04130

Name	Explore in Pharos	Explore in Source
Phagosome	230 targets	path:hsa04145
SNARE interactions in vesicular transport	34 targets	path:hsa04130

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (31)

Functions (4)

Components (19)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
chloride channel inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
SNARE binding	Inferred from Direct Assay (IDA)	MGI
syntaxin binding	Inferred from Physical Interaction (IPI)	UniProtKB
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6	2	6		84.6
red blood cell distribution width	EFO_0005192	4	2	4		82.4
sensory perception of smell	GO_0007608	1	1	1		63.1
reticulocyte measurement	EFO_0010700	3	1	3		42.3
body height	EFO_0004339	1	1	1		40.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6		84.6
red blood cell distribution width	EFO_0005192	4		82.4
sensory perception of smell	GO_0007608	1		63.1
reticulocyte measurement	EFO_0010700	3		42.3
body height	EFO_0004339	1		40.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Direct protein sequencing
Endosome
Membrane
Phosphoprotein
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body height
mean corpuscular volume
red blood cell distribution width
reticulocyte count
reticulocyte measurement
sensory perception of smell
waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntaxin 7	VGNC:3714	463004
Macaque	syntaxin 7		709667
Mouse	syntaxin 7	MGI:1858210	53331
Rat	syntaxin 7	RGD:619747	60466
Dog	syntaxin 7	VGNC:46958	483987

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntaxin 7
Macaque	syntaxin 7
Mouse	syntaxin 7
Rat	syntaxin 7
Dog	syntaxin 7

Publication Statistics

PubMed Score 29.71

PubMed score by year

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PubTator Score 20.00

PubTator score by year

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Related Publications

Text Mined References (41)

GeneRif Annotations (8)

Items per page:

10

0 of 0

PMID	Year	Title