Tbio STX5 Syntaxin-5

Protein Summary

Description

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q13190
• B2R8T2
• F8W8Q9
• Q5U0D4
• Q7Z3T6
• Q9BUG1

Gene Name

• STX5

Ensembl ID

• ENST00000294179
• ENSP00000294179
• ENSG00000162236
• ENST00000377897
• ENSP00000367129
• ENST00000394690
• ENSP00000378182

Symbol

• STX5A
• SED5
• STX5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.86
cellular component	0.74
transcription factor perturbation	0.74
tissue	0.68
transcription factor binding site profile	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-5

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.26   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.26   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0