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Tbio
STX3
Syntaxin-3

Protein Summary
Description
Potentially involved in docking of synaptic vesicles at presynaptic active zones. The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337979
  • ENSP00000338562
  • ENSG00000166900
  • ENST00000529177
  • ENSP00000433248

Symbol
  • STX3A
  • STX3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
PubMedID
0.89
disease perturbation
0.87
transcription factor perturbation
0.84
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.52   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.52   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
STXBP5
Tbio
Novelty:  0.01899802
p_int:  0.999999806
p_ni:  1.94e-7
Score:  0.844
Data Source:  BioPlex,STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
p_int:  0.999998556
p_ni:  0.000001444
Score:  0.935
Data Source:  BioPlex,STRINGDB
STX6
Tbio
Novelty:  0.01494028
p_int:  0.999979536
p_ni:  0.000020182
p_wrong:  2.82e-7
Score:  0.974
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999948772
p_ni:  0.000051129
p_wrong:  9.9e-8
Score:  0.931
Data Source:  BioPlex,STRINGDB
STXBP6
Tbio
Novelty:  0.13195671
p_int:  0.999897963
p_ni:  0.000102028
p_wrong:  9e-9
Score:  0.872
Data Source:  BioPlex,STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
p_int:  0.999854106
p_ni:  0.000145847
p_wrong:  4.7e-8
Score:  0.971
Data Source:  BioPlex,STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
p_int:  0.999779932
p_ni:  0.000220066
p_wrong:  3e-9
Score:  0.967
Data Source:  BioPlex,STRINGDB
LSMEM2
Tdark
Novelty:  43
p_int:  0.999437419
p_ni:  0.000121614
p_wrong:  0.000440967
Data Source:  BioPlex
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.997818598
p_ni:  0.002181253
p_wrong:  1.5e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.997067725
p_ni:  0.002535152
p_wrong:  0.000397123
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin B measurement
1
1
1
46.9
vitamin measurement
1
1
1
42.3
sex hormone-binding globulin measurement
3
1
3
39.6
vitamin B12 measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin B measurement
1
46.9
vitamin measurement
1
42.3
sex hormone-binding globulin measurement
3
39.6
vitamin B12 measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
syntaxin 3
698953
Mouse
MGI:103077
20908
Rat
RGD:621005
81802
Dog
syntaxin 3
VGNC:46955
100855648
Horse
syntaxin 3
VGNC:23730
100060878
Species
Name
OMA
EggNOG
Inparanoid
Macaque
syntaxin 3
Mouse
Rat
Dog
syntaxin 3
Horse
syntaxin 3
Publication Statistics
PubMed Score 93.52
PubMed score by year
PubTator Score 53.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title