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Tbio
STX1B
Syntaxin-1B

Protein Summary
Description
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215095
  • ENSP00000215095
  • ENSG00000099365
  • ENST00000565419
  • ENSP00000455899

Symbol
  • STX1B1
  • STX1B2
  • GEFSP9
  • STX1B1
  • STX1B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cellular component
0.63
gene perturbation
0.62
tissue sample
0.59
biological process
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.04   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.04   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999998451
p_ni:  0.000001549
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999995651
p_ni:  0.000004349
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999992292
p_ni:  0.000007694
p_wrong:  1.4e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999991765
p_ni:  0.000008235
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.999451381
p_ni:  0.000514673
p_wrong:  0.000033945
Score:  0.165
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.996
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.996
Data Source:  STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.992
Data Source:  STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
Score:  0.98
Data Source:  STRINGDB
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Disease
Reactome
Infectious disease
Reactome
LGI-ADAM interactions
Reactome
Neurotoxicity of clostridium toxins
Name
Explore in Pharos
Explore in Source
Developmental Biology
Disease
Infectious disease
LGI-ADAM interactions
Neurotoxicity of clostridium toxins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
83.8
mean reticulocyte volume
1
1
1
82.8
mean corpuscular volume
1
1
1
82.2
response to anticoagulant
1
1
0
20.4
81
triglyceride measurement
3
3
2
2.1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.8
mean reticulocyte volume
1
82.8
mean corpuscular volume
1
82.2
response to anticoagulant
0
20.4
81
triglyceride measurement
2
2.1
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
syntaxin 1B
714251
Mouse
MGI:1930705
56216
Rat
RGD:3784
24923
Dog
syntaxin 1B
VGNC:49723
489918
Cow
syntaxin 1B
VGNC:35437
282377
Species
Name
OMA
EggNOG
Inparanoid
Macaque
syntaxin 1B
Mouse
Rat
Dog
syntaxin 1B
Cow
syntaxin 1B
Publication Statistics
PubMed Score 81.04
PubMed score by year
PubTator Score 30.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title