Protein Summary
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- ENST00000306200
- ENSP00000305810
- ENSG00000168818
- Ufe1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.87 | ||
interacting protein | 0.85 | ||
kinase perturbation | 0.66 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.4 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.4 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (202)
USE1
Novelty: 0.00904756
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NBAS
Novelty: 0.01187862
p_int: 0.999999611
p_ni: 3.89e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
RTL6
Novelty: 0.12824182
p_int: 0.9999986
p_ni: 5.14e-7
p_wrong: 8.85e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
VAMP4
Novelty: 0.02949854
p_int: 0.999997527
p_ni: 0.000002473
Score: 0.948
Data Source: BioPlex,STRINGDB
VAMP8
Novelty: 0.01083228
p_int: 0.999953799
p_ni: 0.00004619
p_wrong: 1.2e-8
Score: 0.894
Data Source: BioPlex,STRINGDB
SEC22B
Novelty: 0.03035448
p_int: 0.999947318
p_ni: 0.000052682
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BNIP1
Novelty: 0.04601895
p_int: 0.999933652
p_ni: 0.000066348
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
STX6
Novelty: 0.01494028
p_int: 0.999903409
p_ni: 0.000096591
Score: 0.955
Data Source: BioPlex,STRINGDB
BET1
Novelty: 0.01791164
p_int: 0.999874073
p_ni: 0.000125869
p_wrong: 5.8e-8
Score: 0.926
Data Source: BioPlex,STRINGDB
VTI1B
Novelty: 0.00955467
p_int: 0.999824229
p_ni: 0.000175771
Score: 0.937
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (5)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | COPI-dependent Golgi-to-ER retrograde traffic | ||||
Reactome | Golgi-to-ER retrograde transport | ||||
Reactome | Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
COPI-dependent Golgi-to-ER retrograde traffic | ||||
Golgi-to-ER retrograde transport | ||||
Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | syntaxin 18 | 712216 | ||||||
Mouse | MGI:1918366 | 71116 | ||||||
Rat | RGD:1310058 | 360953 | ||||||
Dog | syntaxin 18 | VGNC:46952 | 609342 | |||||
Horse | syntaxin 18 | VGNC:23727 | 100056340 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | syntaxin 18 | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 18 | |||||
Horse | syntaxin 18 | |||||
Publication Statistics
PubMed Score 36.40
PubMed score by year
PubTator Score 15.82
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (5)
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