Protein Summary
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
- ENST00000355957
- ENSP00000348229
- ENSG00000124222
- ENST00000358029
- ENSP00000350723
- ENST00000359617
- ENSP00000352634
- ENST00000361830
- ENSP00000354445
- ENST00000371132
- ENSP00000360173
- ENST00000371141
- ENSP00000360183
- ENST00000467096
- ENSP00000434369
- SYN16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
transcription factor binding site profile | 0.99 | ||
cellular component | 0.87 | ||
microRNA | 0.83 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.72 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.72 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0