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Tbio
STX16
Syntaxin-16

Protein Summary
Description
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355957
  • ENSP00000348229
  • ENSG00000124222
  • ENST00000358029
  • ENSP00000350723
  • ENST00000359617
  • ENSP00000352634
  • ENST00000361830
  • ENSP00000354445
  • ENST00000371132
  • ENSP00000360173
  • ENST00000371141
  • ENSP00000360183
  • ENST00000467096
  • ENSP00000434369

Symbol
  • SYN16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor binding site profile
0.99
cellular component
0.87
microRNA
0.83
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
VPS45
Tbio
Novelty:  0.01960939
p_int:  0.999999992
p_ni:  8e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.990959082
p_ni:  0.000332247
p_wrong:  0.008708672
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.986711143
p_ni:  0.000163679
p_wrong:  0.013125178
Score:  0.838
Data Source:  BioPlex,STRINGDB
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.95879442
p_ni:  0.000907739
p_wrong:  0.040297841
Data Source:  BioPlex
NAPA
Tbio
Novelty:  0.00618772
Score:  0.998
Data Source:  Reactome,STRINGDB
STX6
Tbio
Novelty:  0.01494028
Score:  0.997
Data Source:  Reactome,STRINGDB
VTI1A
Tbio
Novelty:  0.04616617
Score:  0.996
Data Source:  Reactome,STRINGDB
NAPB
Tdark
Novelty:  0.31464404
Score:  0.995
Data Source:  STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
Score:  0.994
Data Source:  STRINGDB
STX10
Tbio
Novelty:  0.05193552
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
58.4
alkaline phosphatase measurement
1
1
1
50.6
C-reactive protein measurement
1
1
1
45.7
hemoglobin measurement
1
1
1
44.2
birth weight
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
58.4
alkaline phosphatase measurement
1
50.6
C-reactive protein measurement
1
45.7
hemoglobin measurement
1
44.2
birth weight
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923396
228960
Dog
syntaxin 16
100855649
Cow
syntaxin 16
519624
Pig
syntaxin 16
100144526
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
syntaxin 16
Cow
syntaxin 16
Pig
syntaxin 16
Publication Statistics
PubMed Score 40.08
PubMed score by year
PubTator Score 47.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title