Tbio STX16 Syntaxin-16

Protein Summary

Description

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• O14662
• A6NK32
• A6NN69
• A8MPP0
• B7ZBN1
• B7ZBN2
• B7ZBN3
• E1P5M0
• E1P607
• O14661
• O14663
• O60517
• Q5W084
• Q5W086
• Q5W087
• Q5XKI6
• Q6GMS8
• Q9H0Z0
• Q9H1T7
• Q9H1T8
• Q9UIX5
• Syn16

Gene Name

• STX16

Ensembl ID

• ENST00000355957
• ENSP00000348229
• ENSG00000124222
• ENST00000358029
• ENSP00000350723
• ENST00000359617
• ENSP00000352634
• ENST00000361830
• ENSP00000354445
• ENST00000371132
• ENSP00000360173
• ENST00000371141
• ENSP00000360183
• ENST00000467096
• ENSP00000434369

Symbol

• SYN16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.99
cellular component	0.87
microRNA	0.83
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-16

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.72   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.72   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0