Tbio STX12 Syntaxin-12

Protein Summary

Description

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Uniprot Accession IDs

• Q86Y82
• B1AJQ7
• O95564

Gene Name

• STX12

Ensembl ID

• ENST00000373943
• ENSP00000363054
• ENSG00000117758

Symbol

• STX13
• STX14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor perturbation	0.97
interacting protein	0.86
histone modification site profile	0.81
cellular component	0.77

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-12

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.86   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.86   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (190)

Explore Interacting Targets

1 – 10 of 190

• See Interactions on String-DB

OPTN

Tbio

Novelty:  0.00080427

p_int:  0.999999986

p_ni:  6e-9

p_wrong:  8e-9

Data Source:  BioPlex

STXBP5

Tbio

Novelty:  0.01899802

p_int:  0.999999975

p_ni:  2.4e-8

p_wrong:  1e-9

Score:  0.736

Data Source:  BioPlex,STRINGDB

NAPG

Tbio

Novelty:  0.02295985

p_int:  0.999999768

p_ni:  2.32e-7

Score:  0.858

Data Source:  BioPlex,STRINGDB

VTI1A

Tbio

Novelty:  0.04616617

p_int:  0.999999529

p_ni:  4.62e-7

p_wrong:  9e-9

Score:  0.978

Data Source:  BioPlex,STRINGDB

VTI1B

Tbio

Novelty:  0.00955467

p_int:  0.999999479

p_ni:  5.21e-7

Score:  0.939

Data Source:  BioPlex,STRINGDB

GOSR1

Tbio

Novelty:  0.03139481

p_int:  0.999999338

p_ni:  6.62e-7

Score:  0.982

Data Source:  BioPlex,STRINGDB

ZKSCAN1

Tbio

Family:  TF

Novelty:  0.08190662

p_int:  0.999999165

p_ni:  8.35e-7

Score:  0.183

Data Source:  BioPlex,STRINGDB

NAPB

Tbio

Novelty:  0.31464404

p_int:  0.999998817

p_ni:  5.81e-7

p_wrong:  6.02e-7

Score:  0.77

Data Source:  BioPlex,STRINGDB

STX6

Tbio

Novelty:  0.01494028

p_int:  0.999998537

p_ni:  0.000001463

Score:  0.994

Data Source:  BioPlex,STRINGDB

VAMP8

Tbio

Novelty:  0.01083228

p_int:  0.999998397

p_ni:  0.000001477

p_wrong:  1.26e-7

Score:  0.99

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

KEGG (1)

PathwayCommons (2)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Phagosome	230 targets	path:hsa04145

Name	Explore in Pharos	Explore in Source
Phagosome	230 targets	path:hsa04145

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (2)

Components (13)

Processes (6)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	3	3		81.7
leukocyte count	EFO_0004308	3	3	3		67.3
myeloid white cell count	EFO_0007988	2	2	2		66.5
monocyte count	EFO_0005091	2	1	2		59.1
red blood cell distribution width	EFO_0005192	2	1	2		52.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3		81.7
leukocyte count	EFO_0004308	3		67.3
myeloid white cell count	EFO_0007988	2		66.5
monocyte count	EFO_0005091	2		59.1
red blood cell distribution width	EFO_0005192	2		52.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Coiled coil
Complete proteome
Endosome
Golgi apparatus
Membrane
Phosphoprotein
Polymorphism
Protein transport

GWAS Trait Find Similar Targets

No Header	No Header
granulocyte count
high density lipoprotein cholesterol measurement
leukocyte count
lymphocyte count
monocyte count
myeloid white cell count
platelet count
platelet crit
red blood cell distribution width
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntaxin 12	VGNC:1650	456678
Macaque	syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827]
Mouse	syntaxin 12	MGI:1931027	100226
Rat	syntaxin 12	RGD:620977	65033
Horse	syntaxin 12	VGNC:23725	100056769

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntaxin 12
Macaque	syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827]
Mouse	syntaxin 12
Rat	syntaxin 12
Horse	syntaxin 12

Publication Statistics

PubMed Score 43.86

PubMed score by year

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PubTator Score 4.84

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (5)

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10

0 of 0

PMID	Year	Title