Protein Summary
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
- ENST00000373943
- ENSP00000363054
- ENSG00000117758
- STX13
- STX14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor perturbation | 0.97 | ||
interacting protein | 0.86 | ||
histone modification site profile | 0.81 | ||
cellular component | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.75 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 166 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.75 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 166 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (190)
STXBP5
Novelty: 0.01899802
p_int: 0.999999975
p_ni: 2.4e-8
p_wrong: 1e-9
Score: 0.736
Data Source: BioPlex,STRINGDB
NAPG
Novelty: 0.02295985
p_int: 0.999999768
p_ni: 2.32e-7
Score: 0.858
Data Source: BioPlex,STRINGDB
VTI1A
Novelty: 0.04616617
p_int: 0.999999529
p_ni: 4.62e-7
p_wrong: 9e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
VTI1B
Novelty: 0.00955467
p_int: 0.999999479
p_ni: 5.21e-7
Score: 0.939
Data Source: BioPlex,STRINGDB
GOSR1
Novelty: 0.03139481
p_int: 0.999999338
p_ni: 6.62e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
ZKSCAN1
Family: TF
Novelty: 0.08190662
p_int: 0.999999165
p_ni: 8.35e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
NAPB
Novelty: 0.31464404
p_int: 0.999998817
p_ni: 5.81e-7
p_wrong: 6.02e-7
Score: 0.77
Data Source: BioPlex,STRINGDB
STX6
Novelty: 0.01494028
p_int: 0.999998537
p_ni: 0.000001463
Score: 0.994
Data Source: BioPlex,STRINGDB
VAMP8
Novelty: 0.01083228
p_int: 0.999998397
p_ni: 0.000001477
p_wrong: 1.26e-7
Score: 0.99
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
KEGG (1)
PathwayCommons (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Phagosome | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Phagosome | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (2)
Components (13)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 2 | 2 | 87.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 76 | |||||
monocyte count | 1 | 1 | 1 | 68.8 | |||||
leukocyte count | 2 | 2 | 2 | 65.7 | |||||
red blood cell distribution width | 2 | 1 | 2 | 62.1 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 87.8 | |||||
myeloid white cell count | 2 | 76 | |||||
monocyte count | 1 | 68.8 | |||||
leukocyte count | 2 | 65.7 | |||||
red blood cell distribution width | 2 | 62.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | syntaxin 12 | VGNC:1650 | 456678 | |||||
Macaque | syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827] | |||||||
Mouse | MGI:1931027 | 100226 | ||||||
Rat | RGD:620977 | 65033 | ||||||
Horse | syntaxin 12 | VGNC:23725 | 100056769 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | syntaxin 12 | |||||
Macaque | syntaxin-12 [Source:RefSeq peptide;Acc:NP_001252827] | |||||
Mouse | ||||||
Rat | ||||||
Horse | syntaxin 12 | |||||
Publication Statistics
PubMed Score 24.75
PubMed score by year
PubTator Score 4.84
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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