Tbio STX12 Syntaxin-12

Protein Summary

Description

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Uniprot Accession IDs

• Q86Y82
• B1AJQ7
• O95564

Gene Name

• STX12

Ensembl ID

• ENST00000373943
• ENSP00000363054
• ENSG00000117758

Symbol

• STX13
• STX14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor perturbation	0.97
interacting protein	0.86
histone modification site profile	0.81
cellular component	0.77

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-12

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.86   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.86   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0