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Tbio
STX11
Syntaxin-11

Protein Summary
Description
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367568
  • ENSP00000356540
  • ENSG00000135604

Symbol
  • FHL4
  • HLH4
  • HPLH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.78
virus perturbation
0.76
protein domain
0.73
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.29   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.29   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
STXBP1
Tbio
Novelty:  0.00339098
p_int:  0.999999995
p_ni:  5e-9
Score:  0.737
Data Source:  BioPlex,STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
p_int:  0.999999982
p_ni:  1.8e-8
p_wrong:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
p_int:  0.999999055
p_ni:  9.45e-7
Data Source:  BioPlex
PDZRN3
Tbio
Family:  Enzyme
Novelty:  0.06663842
p_int:  0.999975137
p_ni:  0.000024863
Score:  0.158
Data Source:  BioPlex,STRINGDB
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.999953639
p_ni:  0.000034748
p_wrong:  0.000011613
Data Source:  BioPlex
VAMP8
Tbio
Novelty:  0.01083228
p_int:  0.999928563
p_ni:  0.000071372
p_wrong:  6.4e-8
Score:  0.931
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.999914349
p_ni:  0.000085652
Data Source:  BioPlex
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
p_int:  0.999854935
p_ni:  0.000145062
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
STXBP5
Tbio
Novelty:  0.01899802
p_int:  0.999765437
p_ni:  0.000234545
p_wrong:  1.9e-8
Score:  0.785
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999599087
p_ni:  0.000400913
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
3
89.9
viral load
1
1
1
68.6
monocyte count
2
1
2
49.2
neutrophil percentage of leukocytes
2
1
2
46.1
granulocyte percentage of myeloid white cells
1
1
1
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
89.9
viral load
1
68.6
monocyte count
2
49.2
neutrophil percentage of leukocytes
2
46.1
granulocyte percentage of myeloid white cells
1
44.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
syntaxin 11
699733
Mouse
MGI:1921982
74732
Dog
syntaxin 11
VGNC:46950
484019
Horse
syntaxin 11
VGNC:23724
100066798
Cow
syntaxin 11
VGNC:35431
539960
Species
Name
OMA
EggNOG
Inparanoid
Macaque
syntaxin 11
Mouse
Dog
syntaxin 11
Horse
syntaxin 11
Cow
syntaxin 11
Publication Statistics
PubMed Score 61.29
PubMed score by year
PubTator Score 47.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title