Protein Summary
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
- ENST00000367568
- ENSP00000356540
- ENSG00000135604
- FHL4
- HLH4
- HPLH4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
virus perturbation | 0.76 | ||
protein domain | 0.73 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.29 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 170 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.29 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 170 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (139)
STXBP1
Novelty: 0.00339098
p_int: 0.999999995
p_ni: 5e-9
Score: 0.737
Data Source: BioPlex,STRINGDB
STXBP2
Novelty: 0.01896992
p_int: 0.999999982
p_ni: 1.8e-8
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
PDZRN3
Family: Enzyme
Novelty: 0.06663842
p_int: 0.999975137
p_ni: 0.000024863
Score: 0.158
Data Source: BioPlex,STRINGDB
HSBP1
Novelty: 0.09422832
p_int: 0.999953639
p_ni: 0.000034748
p_wrong: 0.000011613
Data Source: BioPlex
VAMP8
Novelty: 0.01083228
p_int: 0.999928563
p_ni: 0.000071372
p_wrong: 6.4e-8
Score: 0.931
Data Source: BioPlex,STRINGDB
TBK1
Family: Kinase
Novelty: 0.00194753
p_int: 0.999854935
p_ni: 0.000145062
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
STXBP5
Novelty: 0.01899802
p_int: 0.999765437
p_ni: 0.000234545
p_wrong: 1.9e-8
Score: 0.785
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
KEGG (1)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | SNARE interactions in vesicular transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
SNARE interactions in vesicular transport | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (2)
Components (8)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 3 | 89.9 | |||||
viral load | 1 | 1 | 1 | 68.6 | |||||
monocyte count | 2 | 1 | 2 | 49.2 | |||||
neutrophil percentage of leukocytes | 2 | 1 | 2 | 46.1 | |||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 44.1 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 89.9 | |||||
viral load | 1 | 68.6 | |||||
monocyte count | 2 | 49.2 | |||||
neutrophil percentage of leukocytes | 2 | 46.1 | |||||
granulocyte percentage of myeloid white cells | 1 | 44.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | syntaxin 11 | 699733 | ||||||
Mouse | MGI:1921982 | 74732 | ||||||
Dog | syntaxin 11 | VGNC:46950 | 484019 | |||||
Horse | syntaxin 11 | VGNC:23724 | 100066798 | |||||
Cow | syntaxin 11 | VGNC:35431 | 539960 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | syntaxin 11 | |||||
Mouse | ||||||
Dog | syntaxin 11 | |||||
Horse | syntaxin 11 | |||||
Cow | syntaxin 11 | |||||
Publication Statistics
PubMed Score 61.29
PubMed score by year
PubTator Score 47.96
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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