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Tbio
STX10
Syntaxin-10

Protein Summary
Description
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343587
  • ENSP00000339350
  • ENSG00000104915
  • ENST00000587230
  • ENSP00000466298

Symbol
  • SYN10
  • SYN10
  • hsyn10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cellular component
0.64
tissue sample
0.59
protein domain
0.58
transcription factor binding site profile
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999885661
p_ni:  0.000114339
p_wrong:  1e-9
Score:  0.973
Data Source:  BioPlex,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.999731934
p_ni:  0.000268063
p_wrong:  3e-9
Score:  0.762
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999082921
p_ni:  0.000917074
p_wrong:  4e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.99802474
p_ni:  0.001952561
p_wrong:  0.000022699
Score:  0.935
Data Source:  BioPlex,STRINGDB
TMEM200A
Tdark
Novelty:  0.25580793
p_int:  0.998010422
p_ni:  0.001901617
p_wrong:  0.000087961
Score:  0.638
Data Source:  BioPlex,STRINGDB
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.997729358
p_ni:  0.002270172
p_wrong:  4.7e-7
Data Source:  BioPlex
CLEC12A
Tbio
Novelty:  0.01478908
p_int:  0.996541019
p_ni:  0.00345887
p_wrong:  1.11e-7
Score:  0.671
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.994019884
p_ni:  0.005980064
p_wrong:  5.2e-8
Score:  0.816
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.967088187
p_ni:  0.032904463
p_wrong:  0.00000735
Data Source:  BioPlex
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
p_int:  0.942707654
p_ni:  0.057221856
p_wrong:  0.00007049
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
88.4
monocyte count
2
2
2
86.8
platelet crit
1
2
2
77.6
mean platelet volume
2
2
2
76.2
self reported educational attainment
3
3
3
5.9
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
88.4
monocyte count
2
86.8
platelet crit
2
77.6
mean platelet volume
2
76.2
self reported educational attainment
3
5.9
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 10
VGNC:2242
455760
Macaque
syntaxin 10
717208
Dog
syntaxin 10
VGNC:46949
476691
Cow
syntaxin 10
VGNC:35430
525379
Pig
syntaxin 10
100627609
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 10
Macaque
syntaxin 10
Dog
syntaxin 10
Cow
syntaxin 10
Pig
syntaxin 10
Publication Statistics
PubMed Score 13.52
PubMed score by year
PubTator Score 7.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title