Tbio STX10 Syntaxin-10

Protein Summary

Description

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• O60499
• A6NC41
• Q6IAP4
• Q96AE8
• Syn10

Gene Name

• STX10

Ensembl ID

• ENST00000343587
• ENSP00000339350
• ENSG00000104915
• ENST00000587230
• ENSP00000466298

Symbol

• SYN10
• SYN10
• hsyn10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.73
cellular component	0.64
tissue sample	0.59
protein domain	0.58
transcription factor binding site profile	0.58

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-10

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (105)

Explore Interacting Targets

1 – 10 of 105

• See Interactions on String-DB

STX12

Tbio

Novelty:  0.03836262

p_int:  0.999885661

p_ni:  0.000114339

p_wrong:  1e-9

Score:  0.973

Data Source:  BioPlex,STRINGDB

VAMP5

Tbio

Novelty:  0.09958312

p_int:  0.999731934

p_ni:  0.000268063

p_wrong:  3e-9

Score:  0.762

Data Source:  BioPlex,STRINGDB

VAMP4

Tbio

Novelty:  0.02949854

p_int:  0.999082921

p_ni:  0.000917074

p_wrong:  4e-9

Score:  0.997

Data Source:  BioPlex,STRINGDB

STX7

Tbio

Novelty:  0.03109969

p_int:  0.99802474

p_ni:  0.001952561

p_wrong:  0.000022699

Score:  0.935

Data Source:  BioPlex,STRINGDB

TMEM200A

Tdark

Novelty:  0.25580793

p_int:  0.998010422

p_ni:  0.001901617

p_wrong:  0.000087961

Score:  0.638

Data Source:  BioPlex,STRINGDB

KIR2DL1

Tbio

Novelty:  0.00523657

p_int:  0.997729358

p_ni:  0.002270172

p_wrong:  4.7e-7

Data Source:  BioPlex

CLEC12A

Tbio

Novelty:  0.01478908

p_int:  0.996541019

p_ni:  0.00345887

p_wrong:  1.11e-7

Score:  0.671

Data Source:  BioPlex,STRINGDB

STX11

Tbio

Novelty:  0.01670743

p_int:  0.994019884

p_ni:  0.005980064

p_wrong:  5.2e-8

Score:  0.816

Data Source:  BioPlex,STRINGDB

LRRIQ1

Tdark

Novelty:  1.8251367

p_int:  0.967088187

p_ni:  0.032904463

p_wrong:  0.00000735

Data Source:  BioPlex

LPAR6

Tchem

Family:  GPCR

Novelty:  0.01801122

p_int:  0.942707654

p_ni:  0.057221856

p_wrong:  0.00007049

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

PathwayCommons (1)

Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Retrograde transport at the Trans-Golgi-Network	49 targets	R-HSA-6811440
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Membrane Trafficking	612 targets	R-HSA-199991
Retrograde transport at the Trans-Golgi-Network	49 targets	R-HSA-6811440
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (3)

Components (10)

Processes (6)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
syntaxin binding	Inferred from Physical Interaction (IPI)	UniProtKB
SNAP receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
SNARE binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (20)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	4	4		88.4
monocyte count	EFO_0005091	2	2	2		86.8
platelet crit	EFO_0007985	1	2	2		77.6
mean platelet volume	EFO_0004584	2	2	2		76.2
self reported educational attainment	EFO_0004784	3	3	3	5.9	74.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	4		88.4
monocyte count	EFO_0005091	2		86.8
platelet crit	EFO_0007985	2		77.6
mean platelet volume	EFO_0004584	2		76.2
self reported educational attainment	EFO_0004784	3	5.9	74.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Golgi apparatus
Membrane
Phosphoprotein
Protein transport
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
body height
cognitive function measurement
cortical surface area measurement
heel bone mineral density
hip circumference
household income
intelligence
lymphocyte percentage of leukocytes
mathematical ability

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	syntaxin 10	VGNC:2242	455760
Macaque	syntaxin 10		717208
Dog	syntaxin 10	VGNC:46949	476691
Cow	syntaxin 10	VGNC:35430	525379
Pig	syntaxin 10		100627609

Species	Name	OMA	EggNOG	Inparanoid
Chimp	syntaxin 10
Macaque	syntaxin 10
Dog	syntaxin 10
Cow	syntaxin 10
Pig	syntaxin 10

Publication Statistics

PubMed Score 13.52

PubMed score by year

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PubTator Score 7.37

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title