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Tbio
STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

Protein Summary
Description
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392708
  • ENSP00000376472
  • ENSG00000134910
  • ENST00000529196
  • ENSP00000436962
  • ENST00000531491
  • ENSP00000432820
  • ENST00000649491
  • ENSP00000497336

Symbol
  • ITM1
  • TMC
  • TMC
  • ITM1
  • STT3-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
interacting protein
0.82
transcription factor binding site profile
0.82
pathway
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.24   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.24   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
RPN1
Tbio
Family:  Enzyme
Novelty:  0.00880101
Score:  0.999
Data Source:  STRINGDB
RPN2
Tbio
Family:  Enzyme
Novelty:  0.01796569
Score:  0.999
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.998
Data Source:  STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
Score:  0.997
Data Source:  STRINGDB
MAGT1
Tbio
Novelty:  0.02144318
Score:  0.995
Data Source:  STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
Score:  0.994
Data Source:  STRINGDB
OSTC
Tbio
Family:  Enzyme
Novelty:  0.06699106
Score:  0.976
Data Source:  STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
Score:  0.962
Data Source:  STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.958
Data Source:  STRINGDB
OST4
Tdark
Family:  Enzyme
Novelty:  0.07519513
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
71.2
heel bone mineral density
2
2
2
63
serum alanine aminotransferase measurement
1
1
0
5.7
21.5
platelet count
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
71.2
heel bone mineral density
2
63
serum alanine aminotransferase measurement
0
5.7
21.5
platelet count
1
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STT3A, catalytic subunit of the oligosaccharyltransferase complex
VGNC:7678
451648
Macaque
STT3A, catalytic subunit of the oligosaccharyltransferase complex
717056
Mouse
MGI:105124
16430
Rat
Dog
STT3A, catalytic subunit of the oligosaccharyltransferase complex
VGNC:46948
489300
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STT3A, catalytic subunit of the oligosaccharyltransferase complex
Macaque
STT3A, catalytic subunit of the oligosaccharyltransferase complex
Mouse
Rat
Dog
STT3A, catalytic subunit of the oligosaccharyltransferase complex
Publication Statistics
PubMed Score 99.24
PubMed score by year
PubTator Score 43.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title