Tchem STS Steryl-sulfatase

Protein Summary

Description

Conversion of sulfated steroid precursors to estrogens during pregnancy. This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P08842
• B2RA47

Gene Name

• STS

Ensembl ID

• ENST00000217961
• ENSP00000217961
• ENSG00000101846

Symbol

• ARSC1
• ES
• ASC
• XLI
• ARSC
• SSDD
• ARSC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
chemical	0.86
cellular component	0.77
transcription factor perturbation	0.74
biological term	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Steryl-sulfatase

DTO Classes

Protein / Enzyme / Hydrolase / Steryl-sulfatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.14   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 245   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.14   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 300

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0