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Tchem
STS
Steryl-sulfatase

Protein Summary
Description
Conversion of sulfated steroid precursors to estrogens during pregnancy. This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217961
  • ENSP00000217961
  • ENSG00000101846

Symbol
  • ARSC1
  • ES
  • ASC
  • XLI
  • ARSC
  • SSDD
  • ARSC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
chemical
0.86
cellular component
0.77
transcription factor perturbation
0.74
biological term
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.14   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.14   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 300
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (300)
Irosustat
Rendered image for Irosustat
CHEMBL3601540
Rendered image for CHEMBL3601540
Emate
Rendered image for Emate
CHEMBL3098847
Rendered image for CHEMBL3098847
CHEMBL592131
Rendered image for CHEMBL592131
Protein-Protein Interactions (151)
RETREG2
Tdark
Novelty:  0.18851807
p_int:  0.999561034
p_ni:  0.000284243
p_wrong:  0.000154723
Score:  0.173
Data Source:  BioPlex,STRINGDB
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.99881003
p_ni:  0.001021465
p_wrong:  0.000168505
Score:  0.973
Data Source:  BioPlex,STRINGDB
JAG2
Tbio
Novelty:  0.00176158
p_int:  0.997541032
p_ni:  0.00245894
p_wrong:  2.7e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.99695425
p_ni:  0.003045352
p_wrong:  3.98e-7
Data Source:  BioPlex
FUT8
Tbio
Family:  Enzyme
Novelty:  0.00675388
p_int:  0.996595556
p_ni:  0.003403752
p_wrong:  6.92e-7
Data Source:  BioPlex
LYZL1
Tbio
Family:  Enzyme
Novelty:  0.10945096
p_int:  0.991114877
p_ni:  0.006779716
p_wrong:  0.002105407
Data Source:  BioPlex
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.990421061
p_ni:  0.009578938
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.984773737
p_ni:  0.01505259
p_wrong:  0.000173673
Data Source:  BioPlex
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.969888666
p_ni:  0.030106527
p_wrong:  0.000004807
Data Source:  BioPlex
LRRC8A
Tbio
Novelty:  0.0163093
p_int:  0.950711772
p_ni:  0.049288204
p_wrong:  2.4e-8
Data Source:  BioPlex
Pathways (11)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
21.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
steroid sulfatase
VGNC:14719
465478
Macaque
steroid sulfatase
707799
Rat
RGD:3783
24800
Dog
steroid sulfatase
VGNC:54604
491727
Horse
steroid sulfatase
VGNC:49276
100034102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
steroid sulfatase
Macaque
steroid sulfatase
Rat
Dog
steroid sulfatase
Horse
steroid sulfatase
Publication Statistics
PubMed Score 379.14
PubMed score by year
PubTator Score 1502.31
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title