Tbio STRN3 Striatin-3

Protein Summary

Description

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

Uniprot Accession IDs

• Q13033
• A2RTX7
• A6NHZ7
• Q9NRA5

Gene Name

• STRN3

Ensembl ID

• ENST00000355683
• ENSP00000347909
• ENSG00000196792
• ENST00000357479
• ENSP00000350071

Symbol

• GS2NA
• SG2NA
• SG2NA
• S/G2NA
• PPP2R6B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
kinase perturbation	0.88
protein domain	0.85
histone modification site profile	0.74
hub protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

CTTNBP2NL

Tbio

Novelty:  0.52774527

p_int:  0.999999917

p_ni:  8.3e-8

Score:  0.942

Data Source:  BioPlex,STRINGDB

CTTNBP2

Tbio

Novelty:  0.00241

p_int:  0.999999806

p_ni:  1.94e-7

Score:  0.906

Data Source:  BioPlex,STRINGDB

MOB4

Tbio

Novelty:  0.03238981

p_int:  0.999999699

p_ni:  3.01e-7

Score:  0.96

Data Source:  BioPlex,STRINGDB

SLMAP

Tbio

Novelty:  0.03974856

p_int:  0.999998986

p_ni:  0.000001014

Score:  0.958

Data Source:  BioPlex,STRINGDB

TRAF3IP3

Tbio

Novelty:  0.12180834

p_int:  0.999998805

p_ni:  0.000001195

Score:  0.87

Data Source:  BioPlex,STRINGDB

STRN

Tbio

Novelty:  0.01025814

p_int:  0.999998505

p_ni:  0.000001495

Score:  0.865

Data Source:  BioPlex,STRINGDB

STRN4

Tbio

Novelty:  0.09936184

p_int:  0.999998256

p_ni:  0.000001744

Score:  0.871

Data Source:  BioPlex,STRINGDB

SIKE1

Tbio

Novelty:  0.14549184

p_int:  0.999997603

p_ni:  0.000002396

p_wrong:  2e-9

Score:  0.918

Data Source:  BioPlex,STRINGDB

STRIP1

Tbio

Novelty:  0.13320106

p_int:  0.999997257

p_ni:  0.000002743

Score:  0.963

Data Source:  BioPlex,STRINGDB

STRIP2

Tbio

Novelty:  0.19321125

p_int:  0.999983505

p_ni:  0.00001646

p_wrong:  3.5e-8

Score:  0.965

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (6)

Components (9)

Processes (5)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	UniProtKB
protein phosphatase 2A binding	Inferred from Direct Assay (IDA)	UniProtKB
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
armadillo repeat domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
Rho GTPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
calmodulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	3	3		86.3
brain measurement	EFO_0004464	1	1	0	13.5	73.2
white matter microstructure measurement	EFO_0005674	2	2	2		72.4
cortical surface area measurement	EFO_0010736	1	1	0	9.3	63.4
cortical thickness	EFO_0004840	1	1	0	8.5	58.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		86.3
brain measurement	EFO_0004464	0	13.5	73.2
white matter microstructure measurement	EFO_0005674	2		72.4
cortical surface area measurement	EFO_0010736	0	9.3	63.4
cortical thickness	EFO_0004840	0	8.5	58.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Calmodulin-binding
Coiled coil
Complete proteome
Cytoplasm
Membrane
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
biological sex
blood protein measurement
brain measurement
cortical surface area measurement
cortical thickness
diastolic blood pressure
mean fractional anisotropy measurement
mean platelet volume
platelet count
systolic blood pressure

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	striatin 3	VGNC:6774	452838
Macaque	striatin 3		717081
Mouse	striatin, calmodulin binding protein 3	MGI:2151064	94186
Rat	striatin 3	RGD:621827	114520
Dog	striatin 3	VGNC:46946	480282

Species	Name	OMA	EggNOG	Inparanoid
Chimp	striatin 3
Macaque	striatin 3
Mouse	striatin, calmodulin binding protein 3
Rat	striatin 3
Dog	striatin 3

Publication Statistics

PubMed Score 14.21

PubMed score by year

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PubTator Score 3.59

PubTator score by year

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Related Publications

Text Mined References (28)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title