Tbio STRIP1 Striatin-interacting protein 1

Protein Summary

Description

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q5VSL9
• Q0V925
• Q5VSL8
• Q658K2
• Q6ZV31
• Q8N598
• Q96SN2
• Q9C0A2

Gene Name

• STRIP1

Ensembl ID

• ENST00000369795
• ENSP00000358810
• ENSG00000143093
• ENST00000369796
• ENSP00000358811
• ENST00000485775
• ENSP00000476025

Symbol

• FAM40A
• KIAA1761
• FAM40A
• FAR11A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
histone modification site profile	0.7
tissue	0.61
transcription factor binding site profile	0.59
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0