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Tbio
STRIP1
Striatin-interacting protein 1

Protein Summary
Description
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. This gene encodes a member of the striatin-interacting phosphatase and kinase complex, which is involved in localization of the Golgi body. The encoded protein participates in cytosketelal organization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369795
  • ENSP00000358810
  • ENSG00000143093
  • ENST00000369796
  • ENSP00000358811
  • ENST00000485775
  • ENSP00000476025

Symbol
  • FAM40A
  • KIAA1761
  • FAM40A
  • FAR11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.7
tissue
0.61
transcription factor binding site profile
0.59
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
TRAF3IP3
Tbio
Novelty:  0.12180834
p_int:  0.999999848
p_ni:  1.52e-7
p_wrong:  1e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.99999974
p_ni:  2.6e-7
Score:  0.863
Data Source:  BioPlex,STRINGDB
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999998297
p_ni:  0.000001703
Score:  0.976
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.999997257
p_ni:  0.000002743
Score:  0.963
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999993107
p_ni:  0.000006867
p_wrong:  2.6e-8
Score:  0.919
Data Source:  BioPlex,STRINGDB
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
p_int:  0.999947376
p_ni:  0.000052624
Data Source:  BioPlex
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999838509
p_ni:  0.000161491
Score:  0.948
Data Source:  BioPlex,STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999404315
p_ni:  0.000595685
Data Source:  BioPlex
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  0.99885562
p_ni:  0.00114438
Score:  0.949
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.995749011
p_ni:  0.004250989
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
64.9
self reported educational attainment
1
1
1
62.1
cognitive function measurement
1
1
1
46.9
bone density
2
2
3
45.5
age at first sexual intercourse measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
64.9
self reported educational attainment
1
62.1
cognitive function measurement
1
46.9
bone density
3
45.5
age at first sexual intercourse measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
striatin interacting protein 1
VGNC:1649
469417
Macaque
striatin interacting protein 1
700799
Mouse
MGI:2443884
229707
Rat
RGD:1564249
362012
Dog
striatin interacting protein 1
VGNC:46943
490117
Species
Name
OMA
EggNOG
Inparanoid
Chimp
striatin interacting protein 1
Macaque
striatin interacting protein 1
Mouse
Rat
Dog
striatin interacting protein 1
Publication Statistics
PubMed Score 8.29
PubMed score by year
PubTator Score 8.97
PubTator score by year
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Related Publications
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PMID
Year
Title