Protein Summary
Essential to the formation of horizontal top connectors between outer hair cell stereocilia. This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.17 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 16 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.17 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 16 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (6)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 3 | 2 | 4 | 91.3 | |||||
IGF-1 measurement | 1 | 1 | 1 | 86.8 | |||||
triglyceride measurement | 5 | 1 | 6 | 86.7 | |||||
serum albumin measurement | 1 | 1 | 1 | 86.6 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 86.1 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 4 | 91.3 | |||||
IGF-1 measurement | 1 | 86.8 | |||||
triglyceride measurement | 6 | 86.7 | |||||
serum albumin measurement | 1 | 86.6 | |||||
serum gamma-glutamyl transferase measurement | 2 | 86.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | stereocilin | 100608534 | ||||||
Macaque | stereocilin | 677720 | ||||||
Mouse | MGI:2153816 | 140476 | ||||||
Dog | stereocilin | 478278 | ||||||
Horse | stereocilin | VGNC:51428 | 100056242 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | stereocilin | |||||
Macaque | stereocilin | |||||
Mouse | ||||||
Dog | stereocilin | |||||
Horse | stereocilin | |||||
Publication Statistics
PubMed Score 74.17
PubMed score by year
PubTator Score 24.65
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (7)
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0 of 0
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