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Tbio
STRBP
Spermatid perinuclear RNA-binding protein

Protein Summary
Description
Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348403
  • ENSP00000321347
  • ENSG00000165209
  • ENST00000360998
  • ENSP00000354271
  • ENST00000447404
  • ENSP00000415968

Symbol
  • SPNR
  • p74
  • SPNR
  • ILF3L
  • HEL162
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
interacting protein
0.86
kinase perturbation
0.81
microRNA
0.81
cell line
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
HNRNPR
Tbio
Novelty:  0.06568708
p_int:  0.999999928
p_ni:  7.2e-8
Score:  0.853
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.999999592
p_ni:  4.08e-7
Score:  0.893
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999816704
p_ni:  0.000183296
Score:  0.57
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.99944378
p_ni:  0.000555369
p_wrong:  8.51e-7
Score:  0.727
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.998755944
p_ni:  0.001244056
Data Source:  BioPlex
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.998158347
p_ni:  0.001841653
Data Source:  BioPlex
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.998072621
p_ni:  0.001927379
Score:  0.266
Data Source:  BioPlex,STRINGDB
AURKAIP1
Tchem
Family:  Enzyme
Novelty:  0.19241693
p_int:  0.99762392
p_ni:  0.00237608
Score:  0.248
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.996682039
p_ni:  0.003317961
Data Source:  BioPlex
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.993232533
p_ni:  0.006767466
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
71.4
body height
3
3
3
68
birth weight
2
2
2
67.5
lymphocyte count
2
1
2
59.8
body height at birth
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
71.4
body height
3
68
birth weight
2
67.5
lymphocyte count
2
59.8
body height at birth
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spermatid perinuclear RNA binding protein
695402
Mouse
MGI:104626
20744
Rat
RGD:620673
84476
Dog
spermatid perinuclear RNA binding protein
VGNC:46942
480733
Horse
spermatid perinuclear RNA binding protein
VGNC:23716
100071069
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spermatid perinuclear RNA binding protein
Mouse
Rat
Dog
spermatid perinuclear RNA binding protein
Horse
spermatid perinuclear RNA binding protein
Publication Statistics
PubMed Score 107.86
PubMed score by year
PubTator Score 39.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title