You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STRAP
Serine-threonine kinase receptor-associated protein

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000025399
  • ENSP00000025399
  • ENSG00000023734
  • ENST00000419869
  • ENSP00000392270

Symbol
  • MAWD
  • UNRIP
  • MAWD
  • PT-WD
  • UNRIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
1
disease perturbation
0.95
kinase perturbation
0.91
biological process
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.3   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.3   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
LARP6
Tbio
Novelty:  0.06933013
p_int:  1
Score:  0.77
Data Source:  BioPlex,STRINGDB
SZRD1
Tdark
Novelty:  0.81300551
p_int:  1
Score:  0.25
Data Source:  BioPlex,STRINGDB
ZNFX1
Tdark
Novelty:  0.06228436
p_int:  0.999999976
p_ni:  1.4e-8
p_wrong:  1e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
GEMIN8
Tbio
Novelty:  0.19515325
p_int:  0.999999944
p_ni:  5.6e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
CSDE1
Tbio
Family:  TF
Novelty:  0.02625299
p_int:  0.999999499
p_ni:  5.01e-7
Score:  0.966
Data Source:  BioPlex,STRINGDB
RPRD2
Tdark
Novelty:  0.45063764
p_int:  0.999999444
p_ni:  5.56e-7
Score:  0.656
Data Source:  BioPlex,STRINGDB
TSNAX
Tbio
Novelty:  0.00888891
p_int:  0.999997581
p_ni:  0.000002419
Score:  0.248
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999992285
p_ni:  0.000007694
p_wrong:  2.1e-8
Score:  0.223
Data Source:  BioPlex,STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
p_int:  0.999971257
p_ni:  0.000028743
Score:  0.156
Data Source:  BioPlex,STRINGDB
GEMIN6
Tbio
Novelty:  0.02104816
p_int:  0.999948692
p_ni:  0.000051308
Score:  0.995
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (140)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Reactome
Signaling by TGF-beta family members
Reactome
TGF-beta receptor signaling activates SMADs
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Signal Transduction
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta family members
TGF-beta receptor signaling activates SMADs
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
31.4
mathematical ability
1
1
1
24.5
self reported educational attainment
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
31.4
mathematical ability
1
24.5
self reported educational attainment
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase receptor associated protein
VGNC:5605
465315
Macaque
serine/threonine kinase receptor associated protein
701287
Mouse
MGI:1329037
20901
Rat
RGD:1311114
297699
Dog
serine/threonine kinase receptor associated protein
VGNC:46941
486663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase receptor associated protein
Macaque
serine/threonine kinase receptor associated protein
Mouse
Rat
Dog
serine/threonine kinase receptor associated protein
Publication Statistics
PubMed Score 32.30
PubMed score by year
PubTator Score 733.70
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title