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Tbio
STRADA
STE20-related kinase adapter protein alpha

Protein Summary
Description
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encodin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336174
  • ENSP00000336655
  • ENSG00000266173
  • ENST00000375840
  • ENSP00000365000
  • ENST00000392950
  • ENSP00000376677
  • ENST00000447001
  • ENSP00000398841
  • ENST00000582137
  • ENSP00000462922
  • ENST00000638702
  • ENSP00000491017
  • ENST00000639835
  • ENSP00000492578
  • ENST00000640999
  • ENSP00000491643

Symbol
  • LYK5
  • STRAD
  • LYK5
  • PMSE
  • Stlk
  • STRAD
  • NY-BR-96
  • STRAD alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
histone modification site profile
0.91
kinase perturbation
0.84
virus perturbation
0.72
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.82   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.82   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
p_int:  0.999999963
p_ni:  5e-9
p_wrong:  3.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CAB39L
Tbio
Novelty:  0.15875148
p_int:  0.999999805
p_ni:  1.36e-7
p_wrong:  5.9e-8
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999999354
p_ni:  5.65e-7
p_wrong:  8.1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.999926711
p_ni:  4.9e-7
p_wrong:  0.000072799
Score:  0.747
Data Source:  BioPlex,STRINGDB
LBHD1
Tdark
Novelty:  7.69709763
p_int:  0.750828314
p_ni:  0.000230696
p_wrong:  0.24894099
Score:  0.197
Data Source:  BioPlex,STRINGDB
CAB39
Tbio
Novelty:  0.01592402
Score:  0.999
Data Source:  Reactome,STRINGDB
STK26
Tchem
Family:  Kinase
Novelty:  0.03633178
Score:  0.94
Data Source:  STRINGDB
BRSK2
Tchem
Family:  Kinase
Novelty:  0.01531371
Score:  0.928
Data Source:  STRINGDB
BRSK1
Tchem
Family:  Kinase
Novelty:  0.0267976
Score:  0.928
Data Source:  STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (219)
Energy dependent regulation of mTOR by LKB1-AMPK (R-HSA-380972)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Signal Transduction
Reactome
mTOR signalling
Name
Explore in Pharos
Explore in Source
Energy dependent regulation of mTOR by LKB1-AMPK
Signal Transduction
mTOR signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
94.2
appendicular lean mass
2
1
2
87
hemoglobin measurement
2
2
2
85.8
body height
5
4
6
77.3
red blood cell density measurement
1
1
1
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
94.2
appendicular lean mass
2
87
hemoglobin measurement
2
85.8
body height
6
77.3
red blood cell density measurement
1
71.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STE20-related kinase adaptor alpha
739133
Macaque
STE20-related kinase adaptor alpha
717927
Mouse
MGI:1919399
72149
Rat
RGD:727905
303605
Dog
STE20-related kinase adaptor alpha
VGNC:46939
609377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STE20-related kinase adaptor alpha
Macaque
STE20-related kinase adaptor alpha
Mouse
Rat
Dog
STE20-related kinase adaptor alpha
Publication Statistics
PubMed Score 39.82
PubMed score by year
PubTator Score 24.66
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title