Protein Summary
Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ENST00000267540
- ENSP00000267540
- ENSG00000140022
- ENST00000555447
- ENSP00000450857
- ENST00000614646
- ENSP00000477736
- STN2
- STNB
- STN2
- STNB
- STNB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.9 | ||
cellular component | 0.77 | ||
virus perturbation | 0.76 | ||
cell line | 0.66 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.79 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 19 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.79 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 19 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (186)
AP2S1
Novelty: 0.01931502
p_int: 0.99999997
p_ni: 2.6e-8
p_wrong: 4e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
AP2M1
Novelty: 0.00769368
p_int: 0.999999867
p_ni: 1.33e-7
Score: 0.966
Data Source: BioPlex,STRINGDB
EPS15L1
Novelty: 0.06929299
p_int: 0.999999865
p_ni: 1.35e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
LSR
Novelty: 0.00528058
p_int: 0.999990119
p_ni: 0.000009878
p_wrong: 3e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
CLINT1
Novelty: 0.00945381
p_int: 0.999901492
p_ni: 0.000098369
p_wrong: 1.39e-7
Score: 0.718
Data Source: BioPlex,STRINGDB
SLC25A41
Family: Transporter
Novelty: 1.04918395
p_int: 0.998111089
p_ni: 0.000322264
p_wrong: 0.001566647
Score: 0.528
Data Source: BioPlex,STRINGDB
CCDC32
Novelty: 1.80929769
p_int: 0.98878603
p_ni: 0.001657952
p_wrong: 0.009556018
Data Source: BioPlex
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 2 | 2 | 79.8 | |||||
platelet count | 2 | 2 | 2 | 77.4 | |||||
corneal topography | 1 | 1 | 1 | 76.3 | |||||
platelet crit | 2 | 2 | 2 | 70.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 69.8 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 79.8 | |||||
platelet count | 2 | 77.4 | |||||
corneal topography | 1 | 76.3 | |||||
platelet crit | 2 | 70.4 | |||||
myeloid white cell count | 1 | 69.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | stonin 2 | VGNC:3309 | 467525 | |||||
Macaque | stonin 2 | 708331 | ||||||
Mouse | MGI:1918272 | 108800 | ||||||
Rat | RGD:1311502 | 314349 | ||||||
Dog | stonin 2 | VGNC:46933 | 490815 | |||||
Publication Statistics
PubMed Score 53.79
PubMed score by year
PubTator Score 16.78
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (6)
Items per page:
0 of 0
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