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Tbio
STON2
Stonin-2

Protein Summary
Description
Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating. This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267540
  • ENSP00000267540
  • ENSG00000140022
  • ENST00000555447
  • ENSP00000450857
  • ENST00000614646
  • ENSP00000477736

Symbol
  • STN2
  • STNB
  • STN2
  • STNB
  • STNB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
cellular component
0.77
virus perturbation
0.76
cell line
0.66
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.79   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.79   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.99999997
p_ni:  2.6e-8
p_wrong:  4e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999867
p_ni:  1.33e-7
Score:  0.966
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999999865
p_ni:  1.35e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
LSR
Tbio
Novelty:  0.00528058
p_int:  0.999990119
p_ni:  0.000009878
p_wrong:  3e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.999901492
p_ni:  0.000098369
p_wrong:  1.39e-7
Score:  0.718
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.998111089
p_ni:  0.000322264
p_wrong:  0.001566647
Score:  0.528
Data Source:  BioPlex,STRINGDB
CCDC32
Tdark
Novelty:  1.80929769
p_int:  0.98878603
p_ni:  0.001657952
p_wrong:  0.009556018
Data Source:  BioPlex
EPS15
Tchem
Novelty:  0.00451447
Score:  0.995
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.992
Data Source:  Reactome,STRINGDB
SYT2
Tbio
Novelty:  0.00754735
Score:  0.983
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
79.8
platelet count
2
2
2
77.4
corneal topography
1
1
1
76.3
platelet crit
2
2
2
70.4
myeloid white cell count
1
1
1
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
79.8
platelet count
2
77.4
corneal topography
1
76.3
platelet crit
2
70.4
myeloid white cell count
1
69.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stonin 2
VGNC:3309
467525
Macaque
stonin 2
708331
Mouse
MGI:1918272
108800
Rat
RGD:1311502
314349
Dog
stonin 2
VGNC:46933
490815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stonin 2
Macaque
stonin 2
Mouse
Rat
Dog
stonin 2
Publication Statistics
PubMed Score 53.79
PubMed score by year
PubTator Score 16.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title